Protein Alignment Tbc1d22 and Tbc1d17

DIOPT Version :10

• Sequence 1: NP_650941.3
• Gene: Tbc1d22 / 42498
• FlyBaseID: FBgn0038855
• Length: 546
• Species: Drosophila melanogaster
• Sequence 2: NP_001099728.1
• Gene: Tbc1d17 / 292886
• RGDID: 1309686
• Length: 646
• Species: Rattus norvegicus
• Alignment Length: 535
• Identity: 113/535 - (21%)
• Similarity: 190/535 - (35%)
• Gaps: 136/535 - (25%)

  Fly    39 SGAGPTPGANSSTF-------WK--NSGRRVPGRPSPKRELEKAA-----AVGVAVG-----RGA 84
            ||..|:......||       |.  ::.|..|....|:|..|.::     |..|::|     |.:
  Rat    68 SGGEPSTSEEEPTFDPGYEPDWAVISTVRPRPHLAEPRRGAEPSSPRSSWAFSVSLGELKSIRRS 132

  Fly    85 APG--------------------------SGMVSTFTEYQKSVSDAWDMGDDEFCIISSTEAAAA 123
            .||                          ..::...:.|....|..   .|....::...:.:|.
  Rat   133 KPGLSWAYLVLVTQAGGSLPALHFHRGGTRALLRVLSRYLLLASSP---QDSRLYLVFPQDPSAL 194

  Fly   124 AVGAGDAAH----FSRQVSQTVALNVIETHSRSNQNHNASRSANESGADLVPVSSSSTDDCKEDR 184
            :    |:.|    |.:..|..|:..:.:.:|.:..:.  ||..|.....|.|....::   ..|.
  Rat   195 S----DSFHHLQLFDQDSSNVVSRFLQDPYSTTFSSF--SRVTNFFRGALQPHPEGAS---SPDL 250

  Fly   185 RSLPDSNENRSRLRNYPG-----------RPQLQKISSNCQDSEYETKIEKFQVVLDSPQLDLVA 238
            ..|||....       ||           ||.::: :....:.|:...:.....:.:.|:|.
  Rat   251 PPLPDDEPE-------PGFEVISCVELGQRPTVER-APPVTEEEWNRHVGPEGRLQNVPELK--- 304

  Fly   239 LKKISWSGVPRKMRAVSWRLLSKYL--PPSSERRMAVLESKRQGYQDLRHNYFRVDSQDETQQDT 301
             .:|...|:...:|..:|:.|..||  ..|:|...|.:..|...|..::..:..|.::.|.:...
  Rat   305 -SRIFSGGLSPGLRREAWKFLLGYLSWESSAEEHKAHVRKKTDEYFRMKLQWKSVSAEQERRNSL 368

  Fly   302 ---YRQ-IHIDVPRM-----------NPQIPLFQQQLVQEMFERILFIWAIRHPASGYVQGINDL 351
               ||. |..||.|.           ||.:.|...         ||..:.:.|...|||||::||
  Rat   369 LHGYRSLIERDVSRTDRTNKFYEGPENPGLGLLND---------ILLTYCMYHFDLGYVQGMSDL 424

  Fly   352 VTPFFIVFLQEALTPNTDLEKYDMSTLPEETRNIIEADSFWCLSKFLDCIQDNYIFAQLGIQEKV 416
            ::|...|                       .:|  |.|:|||...|::.:..|:..:|..::.::
  Rat   425 LSPILFV-----------------------VQN--EVDAFWCFCGFMELVHGNFEESQETMKRQL 464

  Fly   417 NQLKDLIQRIDVNLHRHLQAHGVDYLQFSFRWMNNLLTRELPLHCTIRLWDTYLAESDGFALFHL 481
            .||..|::.:|..|...|.:.....|.|.|||:.....||.|....:|||:.......|..| ||
  Rat   465 GQLLLLLRVLDQPLCDFLDSQDSGSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTGLPGPNL-HL 528

  Fly   482 YVCAAFLLHWKEQLM 496
            .|..|.|...::.||
  Rat   529 LVACAILDMERDTLM 543

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d22	NP_650941.3	TBC	243..496	CDD:214540	67/269 (25%)
Tbc1d17	NP_001099728.1	PH_RBD	7..205	CDD:432305	23/143 (16%)
		TBC	308..543	CDD:214540	67/269 (25%)