Protein Alignment CG5745 and TBC1D22A

DIOPT Version :9

• Sequence 1: NP_650941.3
• Gene: CG5745 / 42498
• FlyBaseID: FBgn0038855
• Length: 546
• Species: Drosophila melanogaster
• Sequence 2: XP_016884231.1
• Gene: TBC1D22A / 25771
• HGNCID: 1309
• Length: 549
• Species: Homo sapiens
• Alignment Length: 576
• Identity: 231/576 - (40%)
• Similarity: 313/576 - (54%)
• Gaps: 125/576 - (21%)

  Fly    52 FWKNSGRRVPG-----------------RPSPKRELEKAAAVGVAVGRGAAPGSGMVSTFTEYQK 99
            |||.|..::||                 ..:..|...|.....|...|        ||||.|::.
Human    10 FWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKR--------VSTFQEFES 66

  Fly   100 SVSDAWDMGDDEFCIISSTEAAAAAVGAGDAAHFSRQVSQTVALNVIETHSRS------------ 152
            :.|||||.|:|:      .|..|.|     |...:.:|....|..|:..||:.
Human    67 NTSDAWDAGEDD------DELLAMA-----AESLNSEVVMETANRVLRNHSQRQGRPTLQEGPGL 120

  Fly   153 ------------------------NQNHNASRSANESGADLVPVSSSSTDDCKEDRRSLPDSNEN 193
                                    :::|.:..:  ||.:|..|:..|         :|||
Human   121 QQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPA--ESASDAAPLQRS---------QSLP----- 169

  Fly   194 RSRLRNYPGRPQLQKISSNCQDSEYETKIEKFQVVLDSPQLDLVALKKISWSGVPRKMRAVSWRL 258
            .|......|......:||:.......::::||:.:|..|..||..|:::||||:|:.:|.::|:|
Human   170 HSATVTLGGTSDPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKL 234

  Fly   259 LSKYLPPSSERRMAVLESKRQGYQDLRHNYFRVDSQ-DETQQDTYRQIHIDVPRMNPQIPLFQQQ 322
            ||.|||.:.:||.|.|:.|::.|.....:|:  ||: ||..||||||||||:|||:|: .|..|.
Human   235 LSGYLPANVDRRPATLQRKQKEYFAFIEHYY--DSRNDEVHQDTYRQIHIDIPRMSPE-ALILQP 296

  Fly   323 LVQEMFERILFIWAIRHPASGYVQGINDLVTPFFIVFLQEALTPNTDLEKYDMSTLPEETRNIIE 387
            .|.|:|||||||||||||||||||||||||||||:||:.|.:... :::..|:|.:|.|....||
Human   297 KVTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIEAE-EVDTVDVSGVPAEVLCNIE 360

  Fly   388 ADSFWCLSKFLDCIQ--------------------------------DNYIFAQLGIQEKVNQLK 420
            ||::||:||.||.||                                |||.|||.|||.||..|:
Human   361 ADTYWCMSKLLDGIQTGLELLGSSELPMLASQSAGITDVRHRARPQNDNYTFAQPGIQMKVKMLE 425

  Fly   421 DLIQRIDVNLHRHLQAHGVDYLQFSFRWMNNLLTRELPLHCTIRLWDTYLAESDGFALFHLYVCA 485
            :|:.|||..:||||..|.|.||||:||||||||.||:||.|||||||||.:|.|||:.|||||||
Human   426 ELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLLMREVPLRCTIRLWDTYQSEPDGFSHFHLYVCA 490

  Fly   486 AFLLHWKEQLMQQNDFQGLMLLLQNLPTHNWSDRQINVLLAEAFRLKFTYADAPKH 541
            |||:.|:::::::.|||.|:|.||||||.:|.|..|::|||||:||||.:||||.|
Human   491 AFLVRWRKEILEEKDFQELLLFLQNLPTAHWDDEDISLLLAEAYRLKFAFADAPNH 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5745	NP_650941.3	TBC	243..496	CDD:214540	152/285 (53%)
TBC1D22A	XP_016884231.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	322	1.000	Domainoid score	I1224
eggNOG	1	0.900	-	-		E1_KOG1092
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	438	1.000	Inparanoid score	I1688
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D220411at33208
OrthoFinder	1	1.000	-	-		FOG0002429
OrthoInspector	1	1.000	-	-		otm41398
orthoMCL	1	0.900	-	-		OOG6_101452
Panther	1	1.100	-	-	O	PTHR22957
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R539
SonicParanoid	1	1.000	-	-		X1614
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.860