DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tbc1d22 and RABGAP1

DIOPT Version :10

Sequence 1:NP_650941.3 Gene:Tbc1d22 / 42498 FlyBaseID:FBgn0038855 Length:546 Species:Drosophila melanogaster
Sequence 2:NP_036329.3 Gene:RABGAP1 / 23637 HGNCID:17155 Length:1069 Species:Homo sapiens


Alignment Length:452 Identity:92/452 - (20%)
Similarity:157/452 - (34%) Gaps:136/452 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   135 RQVSQTVALNVIET----------HSRSNQNHNASRSAN--ESGADLVPVSSSSTDDCKEDRRSL 187
            :|:.|....|..:|          ..|..:...||.|..  :||:....:.|...||.:||    
Human   457 KQIKQRERKNNTDTLYEVVCLESESERERRKTTASPSVRLPQSGSQSSVIPSPPEDDEEED---- 517

  Fly   188 PDSNENRSRLRNYPGRPQLQKISSNCQDSEYET---KIEKFQVVLDSPQLDLVALKKISWSGVPR 249
                 |...|.:..|     .:|..|.:...||   .:.|:.:.|:.....|.:|.:   :|||.
Human   518 -----NDEPLLSGSG-----DVSKECAEKILETWGELLSKWHLNLNVRPKQLSSLVR---NGVPE 569

  Fly   250 KMRAVSWRLLS----------KY---LPPSSERRMAVLESKRQGYQDLRHNYFRVDSQDETQQDT 301
            .:|...|:||:          ||   :...|.:..|:.....:.:.  .|:||: |:..:.|...
Human   570 ALRGEVWQLLAGCHNNDHLVEKYRILITKESPQDSAITRDINRTFP--AHDYFK-DTGGDGQDSL 631

  Fly   302 YRQIHIDVPRMNPQIPLFQQQLVQEMFERILFIWAIRHPASGYVQGINDLVTPFFIVFLQEALTP 366
            |                           :|...:::.....||.||.:         ||...|  
Human   632 Y---------------------------KICKAYSVYDEEIGYCQGQS---------FLAAVL-- 658

  Fly   367 NTDLEKYDMSTLPEETRNIIEADSFWCLSKFLDCIQDNYIFAQLGIQE-----------KVNQLK 420
                    :..:|||       .:|..|.|         |....|::|           |..||:
Human   659 --------LLHMPEE-------QAFSVLVK---------IMFDYGLRELFKQNFEDLHCKFYQLE 699

  Fly   421 DLIQRIDVNLHRH-----LQAHGVDYLQFSFRWMNNLLTRELPLHCTIRLWDTYLAESDGFALFH 480
            .|:|....:|:.|     |:||     .::.:|...|.|.:.||:....:.|..|.|  |.::  
Human   700 RLMQEYIPDLYNHFLDISLEAH-----MYASQWFLTLFTAKFPLYMVFHIIDLLLCE--GISV-- 755

  Fly   481 LYVCAAFLLHWKEQLMQQNDFQGLMLLLQ-NLPTHNWSDRQINVLLAEAFRLKFTYADAPKH 541
            ::..|..||...:..:...||:|.:...: .||....|:.....|:..|..:|.:.....|:
Human   756 IFNVALGLLKTSKDDLLLTDFEGALKFFRVQLPKRYRSEENAKKLMELACNMKISQKKLKKY 817

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tbc1d22NP_650941.3 TBC 243..496 CDD:214540 56/281 (20%)
RABGAP1NP_036329.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..79
PTB_Rab6GAP 145..273 CDD:269922
DUF3694 307..437 CDD:463599
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 482..527 13/53 (25%)
TBC 563..772 CDD:214540 56/285 (20%)
SMC_prok_B <825..>1032 CDD:274008
Blue background indicates that the domain is not in the aligned region.

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