DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tbc1d22 and Tbc1d17

DIOPT Version :10

Sequence 1:NP_650941.3 Gene:Tbc1d22 / 42498 FlyBaseID:FBgn0038855 Length:546 Species:Drosophila melanogaster
Sequence 2:NP_001036120.1 Gene:Tbc1d17 / 233204 MGIID:2449973 Length:645 Species:Mus musculus


Alignment Length:515 Identity:114/515 - (22%)
Similarity:180/515 - (34%) Gaps:136/515 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    40 GAGPTPGANSSTF------WKNSGRRVPGRPSPKRELEKAAAVGVAVGRGAAPG--------SGM 90
            ||.|:...:|..|      .|:..|..||       |..|..|.|....|:.|.        ..:
Mouse   106 GAEPSSSRSSWAFSVSLGELKSIRRSKPG-------LSWAYLVLVTQAGGSLPALHFHRGGTRAL 163

  Fly    91 VSTFTEYQKSVSDAWDMGDDEFCIISSTEAAAAAVGAGDAAHFSRQVSQTVALNVIE-------- 147
            :...:.|....|..   .|....::...:.:|.:    |:.|..:...|. :.||:.        
Mouse   164 LRVLSRYLLLASSP---QDSRLYLVFPQDPSALS----DSFHHLQLFDQD-SSNVVSRFLQDPYS 220

  Fly   148 -THSRSNQNHNASRSA------NESGADLVPVSSSSTD------DCKE------DRRSLPDSNEN 193
             |.|..::..|..|.|      ..|..:|.|:.....:      .|.|      ..|:.|.:.|.
Mouse   221 TTFSSFSRVTNFFRGALQPHPEGASSPNLPPLPDDEPEPGFEVISCVELGQRPTVERAPPVTEEE 285

  Fly   194 RSRLRNYPGRPQLQKISSNCQDSEYETKIEKFQVVLDSPQLDLVALKKISWSGVPRKMRAVSWRL 258
            .:|.....||  ||.:                      |:|.    .:|...|:...:|..:|:.
Mouse   286 WNRYVGPEGR--LQNV----------------------PELK----NRIFSGGLSPGLRREAWKF 322

  Fly   259 LSKYL--PPSSERRMAVLESKRQGYQDLRHNYFRVDSQDETQQDT---YRQ-IHIDVPRM----- 312
            |..||  ..|:|...|.:..|...|..::..:..|.::.|.:...   ||. |..||.|.     
Mouse   323 LLGYLSWESSAEEHKAHVRKKTDEYFRMKLQWKSVSAEQERRNSLLHGYRSLIERDVSRTDRTNK 387

  Fly   313 ------NPQIPLFQQQLVQEMFERILFIWAIRHPASGYVQGINDLVTPFFIVFLQEALTPNTDLE 371
                  ||.:.|...         ||..:.:.|...|||||::||::|...|             
Mouse   388 FYEGPENPGLSLLHD---------ILLTYCMYHFDLGYVQGMSDLLSPILFV------------- 430

  Fly   372 KYDMSTLPEETRNIIEADSFWCLSKFLDCIQDNYIFAQLGIQEKVNQLKDLIQRIDVNLHRHLQA 436
                      .:|  |.|:|||...|::.:..|:..:|..::.::.||..|::.:|..|...|.:
Mouse   431 ----------VQN--EVDAFWCFCGFMELVHGNFEESQETMKRQLGQLLLLLRVLDQPLCDFLDS 483

  Fly   437 HGVDYLQFSFRWMNNLLTRELPLHCTIRLWDTYLAESDGFALFHLYVCAAFLLHWKEQLM 496
            .....|.|.|||:.....||.|....:|||:.......|..| ||.|..|.|...::.||
Mouse   484 QDSGSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTGLPGPNL-HLLVACAILDMERDTLM 542

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tbc1d22NP_650941.3 TBC 243..496 CDD:214540 67/269 (25%)
Tbc1d17NP_001036120.1 PH_RBD 7..204 CDD:432305 21/111 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 57..85
Required for interaction with OPTN. /evidence=ECO:0000250 217..309 21/119 (18%)
TBC 307..542 CDD:214540 67/269 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 596..645
Blue background indicates that the domain is not in the aligned region.

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