Protein Alignment Tbc1d22 and Tbc1d10c

DIOPT Version :10

• Sequence 1: NP_650941.3
• Gene: Tbc1d22 / 42498
• FlyBaseID: FBgn0038855
• Length: 546
• Species: Drosophila melanogaster
• Sequence 2: NP_848765.2
• Gene: Tbc1d10c / 108995
• MGIID: 1922072
• Length: 444
• Species: Mus musculus
• Alignment Length: 269
• Identity: 63/269 - (23%)
• Similarity: 97/269 - (36%)
• Gaps: 66/269 - (24%)

  Fly   229 LDSPQLDLVALKKISW-----------------------SGVPRKMRAVSWRLLSKYLPPSSERR 270
            |..|..||:..:::.|                       .|:|..:||..|.||       ...|
Mouse    50 LCQPSADLIRQREMKWVEMTLHWEKTMSRRYKKVKIQCRKGIPSALRARCWPLL-------CGAR 107

  Fly   271 MAVLESKRQG-YQDLRHNYFRVDSQDETQQDTYRQIHIDVPRMNPQIPLFQQQLVQEMFERILFI 334
            |.  :....| ||:|..........:...:|.:||..:....::|| ...||.|:|     :|..
Mouse   108 MC--QKNNPGTYQELAAAPGDPQWMETIGRDLHRQFPLHEMFVSPQ-GHGQQGLLQ-----VLKA 164

  Fly   335 WAIRHPASGYVQGINDLVTPFFIVFLQEALTPNTDLEKYDMSTLPEETRNIIEADSFWCLSKFLD 399
            :.:..|..||.|...    |...|.|..               ||.|       ::||||.:..:
Mouse   165 YTLYRPEQGYCQAQG----PVAAVLLMH---------------LPPE-------EAFWCLVQICE 203

  Fly   400 CIQDNYIFAQL-GIQEKVNQLKDLIQRIDVNLHRHLQAHGVDYLQFSFRWMNNLLTRELPLHCTI 463
            .....|....: .:|........|::|....:::|||..||..|.:...|...|.||.||....:
Mouse   204 VYLPGYYGPHMEAVQLDAEVFMALLRRQLPRVYKHLQQVGVGPLLYLPEWFLCLFTRSLPFPTVL 268

  Fly   464 RLWDTYLAE 472
            |:||.:|:|
Mouse   269 RIWDAFLSE 277

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d22	NP_650941.3	TBC	243..496	CDD:214540	59/255 (23%)
Tbc1d10c	NP_848765.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..32
		TBC	87..292	CDD:214540	58/232 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	383..444
		Interaction with calcineurin. /evidence=ECO:0000250	404..444