DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP93B and ARHGAP25

DIOPT Version :9

Sequence 1:	NP_650939.2	Gene:	RhoGAP93B / 42496	FlyBaseID:	FBgn0038853	Length:	1330	Species:	Drosophila melanogaster
Sequence 2:	XP_016860912.1	Gene:	ARHGAP25 / 9938	HGNCID:	28951	Length:	650	Species:	Homo sapiens

Alignment Length:	334	Identity:	83/334 - (24%)
Similarity:	138/334 - (41%)	Gaps:	67/334 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  1029 TTENP-----------KRDSLIRGWE-----LMAICLSYVPPSPTFQPTLLNYVNRHRDPSFATC 1077
            :|.||           |:.|:::.|:     |.|..|.|.......:|....|:........||.
Human    43 STPNPLERPIKMGWLKKQRSIVKNWQQRYFVLRAQQLYYYKDEEDTKPQGCMYLPGCTIKEIATN 107

  Fly  1078 FMEVSKWPIHVQISHYATVCCRRLDRIGSSG------------------RRMAKKPTVDEVEQAR 1124
            ..|..|:...:..:.:..      :|:|...                  ||:|..|.
Human   108 PEEAGKFVFEIIPASWDQ------NRMGQDSYVLMASSQAEMEEWVKFLRRVAGTPC-------- 158

  Fly  1125 QQILRNSMFGNTLSEVMDLQKEKFPFRKLPWIQTTLSEHVLLLNGKQTEGIFRVSADVDEVGCMK 1189
                 .::||..|.|.: ..::||....:|.:....:|.: |.:|:..|||||:....:.|..::
Human   159 -----GAVFGQRLDETV-AYEQKFGPHLVPILVEKCAEFI-LEHGRNEEGIFRLPGQDNLVKQLR 216

  Fly  1190 NRLDRWDVPDYKNTLVDAHTPASLLKLWYRELYDPLIPDAYYED---CVNTEDPDKAK---EIVN 1248
            :..|..:.|.:... .|.||.||||||:.|:|.:|::|.:.||.   |....:.|:||   |::.
Human   217 DAFDAGERPSFDRD-TDVHTVASLLKLYLRDLPEPVVPWSQYEGFLLCGQLTNADEAKAQQELMK 280

  Fly  1249 K---LPEINQLVLTYLIHFLQQFAIPEVVSCTKMDSSNLAMVFAPNCLRCTSEDPKVILENARKE 1310
            :   ||..|..:|:|:..||.:..:...|:  ||...|||.|...|.:|...|||.||:....:.
Human   281 QLSILPRDNYSLLSYICRFLHEIQLNCAVN--KMSVDNLATVIGVNLIRSKVEDPAVIMRGTPQI 343

  Fly  1311 MSFMRTLIQ 1319
            ...|..:|:
Human   344 QRVMTMMIR 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP93B	NP_650939.2	WW	50..75	CDD:278809
		MyTH4	956..1122	CDD:295320	22/126 (17%)
		RhoGAP_KIAA1688	1133..1320	CDD:239854	61/196 (31%)
ARHGAP25	XP_016860912.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910