DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP93B and ARHGAP24

DIOPT Version :9

Sequence 1:	NP_650939.2	Gene:	RhoGAP93B / 42496	FlyBaseID:	FBgn0038853	Length:	1330	Species:	Drosophila melanogaster
Sequence 2:	NP_001020787.2	Gene:	ARHGAP24 / 83478	HGNCID:	25361	Length:	748	Species:	Homo sapiens

Alignment Length:	218	Identity:	70/218 - (32%)
Similarity:	104/218 - (47%)	Gaps:	19/218 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly  1118 DEVEQARQQI---LRNSMFGNTLSEVMDLQKEKFPFRKLPWIQTTLSEHVLLLNGKQTEGIFRVS 1179
            |.|:..|:.|   ....:||..|.:.:..:| ::..|..|.:.....:.: ...|.:.||:||:.
Human   115 DWVKSIRRVIWGPFGGGIFGQKLEDTVRYEK-RYGNRLAPMLVEQCVDFI-RQRGLKEEGLFRLP 177

  Fly  1180 ADVDEVGCMKNRLDRWDVPDY-KNTLVDAHTPASLLKLWYRELYDPLIPDAYYED---C---VNT 1237
            ...:.|..:::..|..:.|.: .||  |.||.||||||:.|||.:|:||.|.|||   |   ::.
Human   178 GQANLVKELQDAFDCGEKPSFDSNT--DVHTVASLLKLYLRELPEPVIPYAKYEDFLSCAKLLSK 240

  Fly  1238 EDPDKAKEI---VNKLPEINQLVLTYLIHFLQQFAIPEVVSCTKMDSSNLAMVFAPNCLRCTSED 1299
            |:....||:   |..||.:|..:|.|:..||.:  :.......||...|||.||.||.||...||
Human   241 EEEAGVKELAKQVKSLPVVNYNLLKYICRFLDE--VQSYSGVNKMSVQNLATVFGPNILRPKVED 303

  Fly  1300 PKVILENARKEMSFMRTLIQHMD 1322
            |..|:|........|..:|...|
Human   304 PLTIMEGTVVVQQLMSVMISKHD 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP93B	NP_650939.2	WW	50..75	CDD:278809
		MyTH4	956..1122	CDD:295320	2/3 (67%)
		RhoGAP_KIAA1688	1133..1320	CDD:239854	65/196 (33%)
ARHGAP24	NP_001020787.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		PH_RhoGap24	18..131	CDD:241530	4/15 (27%)
		PH	21..124	CDD:278594	3/8 (38%)
		RhoGAP_ARHGAP22_24_25	131..329	CDD:239855	66/202 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	354..476
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	582..641
		ATG16	<609..>723	CDD:285778
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910