Protein Alignment RhoGAP93B and ARHGAP39

DIOPT Version :10

• Sequence 1: NP_650939.2
• Gene: RhoGAP93B / 42496
• FlyBaseID: FBgn0038853
• Length: 1330
• Species: Drosophila melanogaster
• Sequence 2: NP_079527.1
• Gene: ARHGAP39 / 80728
• HGNCID: 29351
• Length: 1114
• Species: Homo sapiens
• Alignment Length: 1378
• Identity: 426/1378 - (30%)
• Similarity: 594/1378 - (43%)
• Gaps: 344/1378 - (24%)

  Fly     7 RIEWVEIIEPRTKEHMYANLTTGECVWDPPEDVPIKRTDSSQWWELFDTNTQRFYYYNAATQKTV 71
            |:||||||||||:|.|||||.|||||||||..|.||||..:|||||||.||.|||||||:||:||
Human    27 RLEWVEIIEPRTRERMYANLVTGECVWDPPAGVRIKRTSENQWWELFDPNTSRFYYYNASTQRTV 91

  Fly    72 WHRPSKCDIIPLAKLQTLKQNTDPSERREQTTPQKQQQQQVQHASQQQQHPSPMSGPNKKGRGQQ 136
            ||||..||||||||||||||||:......:::|                           |||.
Human    92 WHRPQGCDIIPLAKLQTLKQNTESPRASAESSP---------------------------GRGS- 128

  Fly   137 RISGGNGTVASSEEKLTSSEVISSPRGRQSFRVSTGDSSRSMDMQQQ--HPQGYASRRSQDSCNQ 199
                     :.|.|..|||.:...|           |:.::.::..:  .|..:.:.:
Human   129 ---------SVSREGSTSSSLEPEP-----------DTEKAQELPARAGRPAAFGTVK------- 166

  Fly   200 YKESGKSSDSSLSSAHGYRRFNDSGVPVSGHPDNLRLGSLQKQQRGGGKDNGAFEMLQESTSSHN 264
             ::||.||...:.....|..:.|  ....|...:.|..||  :...|.|:....::
Human   167 -EDSGSSSPPGVFLEKDYEIYRD--YSADGQLLHYRTSSL--RWNSGAKERMLIKV--------- 217

  Fly   265 LPHGSTSTSSSYAGGSGYGDKYFDHQLLPNHLQGYSSKSSDIASPTHSIHTPQSQKKKMSPDAAP 329
               .....|...|.|:||.         |:...|..|:     .|:.|.|:|..|  ..:|:|..
Human   218 ---ADREPSFLAAQGNGYA---------PDGPPGVRSR-----RPSGSQHSPSLQ--TFAPEADG 263

  Fly   330 AAQYNYAQQQHQQRSAQRSGGGA---AGTGAPAGKSYGGDREYKVSLARSGSFMSSSINPAAAGH 391
            ...:...:.....:.|:..|..:   |....|:|.|......|                    |:
Human   264 TIFFPERRPSPFLKRAELPGSSSPLLAQPRKPSGDSQPSSPRY--------------------GY 308

  Fly   392 HSKSYRKSSAEAANGGAASDDSMHEKYFKSVENTPLSRRRHTTNATKSGGGASGSNTATSTAGSG 456
            ....|.:...|               |...:.:.|....:.     ::|||..        ||
Human   309 EPPLYEEPPVE---------------YQAPIYDEPPMDVQF-----EAGGGYQ--------AG-- 343

  Fly   457 SSSHKKHSSDSSPQSPISPQTKSSRQAKTSATSTVPQLQHSPRLQEPSHSLDLLSLER------- 514
                             |||....|:.:       |.||  |..|.|......|.|.:
Human   344 -----------------SPQRSPGRKPR-------PFLQ--PNKQGPPSPCQQLVLTKQKCPERF 382

  Fly   515 ISLGKSGPISPGGGTENLGLLTHSSRGSNDSARQRQKSNNSSANRSQSHHY---PGQSSLRHSAS 576
            :||    ..||.|......|:.....||:...|...:           |.|   ||..|.....|
Human   383 LSL----EYSPAGKEYVRQLVYVEQAGSSPKLRAGPR-----------HKYAPNPGGGSYSLQPS 432

  Fly   577 SSLDKRGYHVGGGSGDGRGVTGGEKRRSKQHHYQQQADNSDVEYDNGNTSPLYTNWDQEMPHLLP 641
            ..| .|...:|..|||...:.|.|.|.|:......||....:            :|..:...|
Human   433 PCL-LRDQRLGVKSGDYSTMEGPELRHSQPPTPLPQAQEDAM------------SWSSQQDTL-- 482

  Fly   642 LKHYIIEQAKLSGRYEYRGGDGGDSDSYHSDSQSEHSLSGHEPDNEDSDGGSDTHG-GYLEHNYG 705
                                   .|..|...::...|   .:|....:...:.|.| |.|.....
Human   483 -----------------------SSTGYSPGTRKRKS---RKPSLCQATSATPTEGPGDLLVEQP 521

  Fly   706 MIDDYANMGDSVSYYAYMYPPHDPAGREDISENVEAVLEGIGGNATEPSAPTATAPKPKPRYQIS 770
            :.::....|.|::          |..|      .|...||..| |.||....|         :::
Human   522 LAEEQPPCGTSLA----------PVKR------AEGEAEGARG-AAEPFLAQA---------RLA 560

  Fly   771 YYDTVSHSPSAGSGYHGQQLYSNTPPYSGHGHGHHVPPPSLPHQQQLHLEPSDTKQKQSQTLPSP 835
            :....:|       :|.:|..|......|.|   :....:||                   ||.|
Human   561 WEAQQAH-------FHMKQRSSWDSQQDGSG---YESDGALP-------------------LPMP 596

  Fly   836 NRQISRL----AGAGHQGSGPAASSKEETGHSTVAGQQQVTVGTVTPASLSRPGHKMAPPSLKPT 896
            ...:...    |.|..:.......:.|:.|...:..::.|:|.|    :|:.|     .|.|.|:
Human   597 GPVVRAFSEDEALAQQENRHWRRGTFEKLGFPQILLEKSVSVQT----NLASP-----EPYLHPS 652

  Fly   897 IQQIFPPSERAPGMGNLGLGGPTLACM----------KECDIEKFAADNLNLHSKGIFRKKASVR 951
            ..:......:.........|.|:.:|:          .|.|||.:|:.:.|.|::|:||:|.|:.
Human   653 QSEDLAACAQFESSRQSRSGVPSSSCVFPTFTLRKPSSETDIENWASKHFNKHTQGLFRRKVSIA 717

  Fly   952 DMLSWTAEAISRPMLALSRDKADKKTAIELFKLVQIYMADRKARIGMTLNSVAIEIISASLPQQQ 1016
            :||:|::|:|.:||:..| |:..||.|.|||||:|:||.||:|:....  .||:|:.:.....|.
Human   718 NMLAWSSESIKKPMIVTS-DRHVKKEACELFKLIQMYMGDRRAKADPL--HVALEVATKGWSVQG 779

  Fly  1017 LRDELYVQLCRQTTENPKRDSLIRGWELMAICLSYVPPSPTFQPTLLNYVNRHRDPSFATCFMEV 1081
            ||||||:|||||||||.:.:||.||||||||||::.||:|.|...|..|:.||.||...|...:.
Human   780 LRDELYIQLCRQTTENFRLESLARGWELMAICLAFFPPTPKFHSYLEGYIYRHMDPVNDTKVTQH 844

  Fly  1082 SK----------------------WPIHVQISHYATVCCRRLDRIGSSG-RRMAKKPTVDEVEQA 1123
            .|                      .|..|.||.||..|..:|.:...:| ::..|||.|:|:..|
Human   845 IKELLERNTKKKSKLRKKPKPYVEEPDGVAISTYAKYCYHKLQKAALTGAKKGLKKPNVEEIRHA 909

  Fly  1124 RQQILRNSMFGNTLSEVMDLQKEKFPFRKLPWIQTTLSEHVLLLNGKQTEGIFRVSADVDEVGCM 1188
            :..:...||||:.|.|||.:|:|::|.|:|||:||.|||.||.|||.||||||||..|:|||..:
Human   910 KNAVFSPSMFGSALQEVMGMQRERYPERQLPWVQTRLSEEVLALNGDQTEGIFRVPGDIDEVNAL 974

  Fly  1189 KNRLDRWDVPDYKNTLVDAHTPASLLKLWYRELYDPLIPDAYYEDCV-NTEDPDKAKEIVNKLPE 1252
            |.::|:|.||   ..|.|.|.||||||||||||.:||||..:||.|: :.:.|:.|..:|:.||.
Human   975 KLQVDQWKVP---TGLEDPHVPASLLKLWYRELEEPLIPHEFYEQCIAHYDSPEAAVAVVHALPR 1036

  Fly  1253 INQLVLTYLIHFLQQFAIPEVVSCTKMDSSNLAMVFAPNCLRCTSEDPKVILENARKEMSFMRTL 1317
            ||::||.|||.|||.|..|..|:.||||.||||||.|||||||.|:||:||.||.||||||:|.|
Human  1037 INRMVLCYLIRFLQVFVQPANVAVTKMDVSNLAMVMAPNCLRCQSDDPRVIFENTRKEMSFLRVL 1101

  Fly  1318 IQHMDTTHVANLV 1330
            |||:||:.:..::
Human  1102 IQHLDTSFMEGVL 1114

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP93B	NP_650939.2	PRP40	1..>75	CDD:227435	53/67 (79%)
		PAT1	<737..>892	CDD:401645	28/158 (18%)
		MyTH4	1004..1122	CDD:459939	56/140 (40%)
		RhoGAP_KIAA1688	1133..1320	CDD:239854	113/187 (60%)
ARHGAP39	NP_079527.1	PRP40	19..>95	CDD:227435	53/67 (79%)
		PHA03307	115..>369	CDD:223039	66/417 (16%)
		PHA03378	<245..543	CDD:223065	78/447 (17%)
		MyTH4	767..908	CDD:459939	56/140 (40%)
		RhoGAP_KIAA1688	919..1104	CDD:239854	113/187 (60%)