Protein Alignment RhoGAP93B and arhgap46b

DIOPT Version :9

• Sequence 1: NP_650939.2
• Gene: RhoGAP93B / 42496
• FlyBaseID: FBgn0038853
• Length: 1330
• Species: Drosophila melanogaster
• Sequence 2: XP_005162072.1
• Gene: arhgap46b / 568268
• ZFINID: ZDB-GENE-090312-60
• Length: 1060
• Species: Danio rerio
• Alignment Length: 1388
• Identity: 402/1388 - (28%)
• Similarity: 587/1388 - (42%)
• Gaps: 396/1388 - (28%)

  Fly     7 RIEWVEIIEPRTKEHMYANLTTGECVWDPPEDVPIKRTDSSQWWELFDTNTQRFYYYNAATQKTV 71
            |.:||||:|||::|.||.||.||||.|:||...|::::|.:|||||||:|..||||||..:|:||
Zfish     5 RSDWVEIVEPRSRERMYVNLLTGECGWEPPPGAPVRQSDGNQWWELFDSNNNRFYYYNCTSQQTV 69

  Fly    72 WHRPSKCDIIPLAKLQTLKQNTDPSERREQTTPQKQQQQQVQHAS-QQQQHPSPMSGPNKKGRGQ 135
            ||||...||:|||:||.:|::::         ...:.|.::|... ..::.|.|
Zfish    70 WHRPQDSDIVPLAQLQAMKRSSE---------ADLKAQGRIQRGPVDGKRTPLP----------- 114

  Fly   136 QRISGGNGTVASSEEKLTSSEVISSPRGRQSFRVSTGDSSRSMDMQQQHPQGYASRRSQDSCNQY 200
                   |...|:.|:.:..|:.|              |:...|..::..||     ::|:..::
Zfish   115 -------GLDPSTLEQESGREIPS--------------SNSKEDSLEKRGQG-----NRDAAQRW 153

  Fly   201 KESGKSSDSSLSSAHGYRRFNDSGVPVSGHPDNLRLGSLQKQQRGGGKDNGAFEMLQESTSSHNL 265
            :.:..|..:.|...:.:.| |.|..|.|.    |.|..|.....|
Zfish   154 QPAPGSKAAMLVKVNSFGR-NQSLGPASA----LHLLHLNPTNNG-------------------- 193

  Fly   266 PHGSTSTSSSYAG-----------GSGY----GDKYFDHQLLPNHLQGYSSKSSDIASPTHSIHT 315
                ||....|.|           ..||    ||..| ..:||:.:.....:.|...:|..|  :
Zfish   194 ----TSFKPGYTGQLTKMAAPGDSKQGYHLKKGDANF-CLVLPSSISSSGHQRSGAGTPRPS--S 251

  Fly   316 PQSQKKKMSP--DAAPAAQ---YNYAQQQHQQRSAQRSGGGAAGTGAPAGKSYGGDREYKVSLAR 375
            ||......:|  |..||..   |:....:.:...|.....|...|..|.|.......::.
Zfish   252 PQYGATPSAPIYDEPPALDAPIYDEPPVEMEVEGAHHLHRGPYSTSLPRGTQPPKLLQFP----- 311

  Fly   376 SGSFMSSSINPAAAGHHSKSYRKSSAEAANGGAASDDSMHEKYFKSVENTPLSRR--RHTTNATK 438
                            |:|....|||.                    |.:|..|.  :|..|...
Zfish   312 ----------------HNKHICSSSAS--------------------EYSPAGRECIKHMVNVDA 340

  Fly   439 SGGGASGSNTATSTAGSGSSSHKKHSSDSSPQSPISPQTKSSRQAKTSATSTVPQLQHSPRLQEP 503
            :   ||......|.|..|:||  ..|....||||:|.|.|.....         :.:.|.||.||
Zfish   341 T---ASKHQPQISNAIEGTSS--STSPQIQPQSPVSAQIKKEVSL---------EKKQSWRLLEP 391

  Fly   504 SHSLDLLSLERISLGKSGPISPGGGTENLGLLTHSSRGSNDSARQRQKSNNSSANRSQSHHYPGQ 568
            .||                                          ||.|       ..|..|||.
Zfish   392 RHS------------------------------------------RQSS-------LASQEYPGP 407

  Fly   569 SSLRHSASSSLDKRGYHVGG--------------GSGDGR-GVTGGEKRRSKQHHYQQQADNSDV 618
            :::.:..|      ||..|.              |:|.|| |..|
Zfish   408 AAVTYQDS------GYSTGPSPSLRRKNRRRAALGTGSGRPGSVG-------------------- 446

  Fly   619 EYDNGNTSPLYTNWDQEMPHLLPLKHYIIEQAKLSGRYEYRGGDGGDSDSYHSDSQSEHSLSGHE 683
              .:|..|.|......||..::                       ..|:::|.   |:.||
Zfish   447 --SSGELSALNEKLMAEMRAVV-----------------------NRSNAHHG---SKASL---- 479

  Fly   684 PDNEDSDGGSDTHGGYLEHNYGMIDDYANMGDSVSYYAYMYPPHDPAGREDISENVEAVLEGIGG 748
                |::.||:..|.........:...|..|.|               |||::.:..::..
Zfish   480 ----DTEMGSEASGSTARSPVSSLKIGARGGGS---------------REDVTSSNRSLCR---- 521

  Fly   749 NATEPSAPTATAPKPKPRYQISYYDTVSHSPSAGSGYHGQQLYSNTPPYSGHGHGHHVPPPSLPH 813
                                            ||:..||..:.|   |....|.|..   ....:
Zfish   522 --------------------------------AGASNHGDVMLS---PLVTDGLGSR---QKRTY 548

  Fly   814 QQQLHLEPSDTKQKQSQTLPSPNRQISRLAGAGHQGSGPAASSKEETGHSTVAGQQQVTVGTVTP 878
            ::...||.|.|.| .|.:.|.|.|..|:        :|...|..::...:.....::...|.
Zfish   549 EKVDSLEKSGTSQ-TSLSSPEPPRSSSQ--------TGTLESKIQQDSTTRDCDHERAGRGN--- 601

  Fly   879 ASLSRPGHKMAPPSLKPTIQQIFPPSERAPGMGNLGLGGPTLACMKECDIEKFAADNLNLHSKGI 943
            |.::|..:..:||....:....:|.|.         |..||    .:.::|.:|:.|||.|::|:
Zfish   602 AHITRKNNNNSPPPSNTSTGYQYPYST---------LCKPT----PDTNMEDWASKNLNQHTQGL 653

  Fly   944 FRKKASVRDMLSWTAEAISRPMLALSRDKADKKTAIELFKLVQIYMADRKARIGMTLNSVAIEII 1008
            ||::.|:.:||||...:|.:||| ::.|:|.||.|.|:|||||.||.||..|:..  :..|::::
Zfish   654 FRRRVSIANMLSWNRGSIKKPML-ITNDRAIKKEACEMFKLVQAYMGDRPVRLDK--HHAALQVV 715

  Fly  1009 SASLPQQQLRDELYVQLCRQTTENPKRDSLIRGWELMAICLSYVPPSPTFQPTLLNYVNRHRDPS 1073
            :.....|.|||||||||.||||:|....||..|||||||.|::..|||.|:..|..|:.||.:||
Zfish   716 TKCWGMQGLRDELYVQLVRQTTDNLCLRSLESGWELMAISLAFFSPSPKFRHYLEGYIQRHLEPS 780

  Fly  1074 FATCFME--VSKWPIH----------------------VQISHYATVCCRRLDRIG-SSGRRMAK 1113
            .....::  :.:..|.                      :.||.||..|.|:|.::. :.|::..:
Zfish   781 NDKKILQNIMEQQDIKNKKNSKSRKKRRQNNDEGEDEGLPISTYAKYCYRKLQKVAITGGKKGLR 845

  Fly  1114 KPTVDEVEQARQQILRNSMFGNTLSEVMDLQKEKFPFRKLPWIQTTLSEHVLLLNGKQTEGIFRV 1178
            |||::|::.:|..|:..|:||:.|.|:|:.|.|.||.|||||:|..||:.||.|.|.||||||||
Zfish   846 KPTLEEIDHSRNAIVTPSLFGSALEEIMERQSELFPDRKLPWVQVQLSQCVLALGGAQTEGIFRV 910

  Fly  1179 SADVDEVGCMKNRLDRWDVPDYKNTLVDAHTPASLLKLWYRELYDPLIPDAYYEDCV-NTEDPDK 1242
            ..|:|||..:|.::|:|.:|:   .|.|.:.||||||||||||.:|:||.::|:.|: :.||||.
Zfish   911 PGDIDEVNALKLQVDQWKIPE---NLSDPNVPASLLKLWYRELEEPVIPQSFYKQCISHYEDPDA 972

  Fly  1243 AKEIVNKLPEINQLVLTYLIHFLQQFAIPEVVSCTKMDSSNLAMVFAPNCLRCTSEDPKVILENA 1307
            |..:|..|||:|:|||.|||:|||.||.|..||.||||.:|||||.|||||||.|:||::|.||.
Zfish   973 AVNVVQSLPELNRLVLCYLINFLQVFAQPVNVSRTKMDVNNLAMVMAPNCLRCQSDDPRIIFENT 1037

  Fly  1308 RKEMSFMRTLIQHMDTTHVANLV 1330
            ||||||:|.||.|:||:.:..|:
Zfish  1038 RKEMSFLRILIVHLDTSFIKGLI 1060

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP93B	NP_650939.2	WW	50..75	CDD:278809	17/24 (71%)
		MyTH4	956..1122	CDD:295320	70/190 (37%)
		RhoGAP_KIAA1688	1133..1320	CDD:239854	111/187 (59%)
arhgap46b	XP_005162072.1	WW	47..73	CDD:278809	18/25 (72%)
		MyTH4	666..852	CDD:295320	69/188 (37%)
		RhoGAP_KIAA1688	865..1050	CDD:239854	111/187 (59%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593685
Domainoid	1	1.000	175	1.000	Domainoid score	I3589
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1123653at2759
OrthoFinder	1	1.000	-	-		FOG0003397
OrthoInspector	1	1.000	-	-		otm26190
orthoMCL	1	0.900	-	-		OOG6_103785
Panther	1	1.100	-	-	O	PTHR45876
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3107
SonicParanoid	1	1.000	-	-		X3852
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.880