Protein Alignment RhoGAP93B and Arhgap39

DIOPT Version :9

• Sequence 1: NP_650939.2
• Gene: RhoGAP93B / 42496
• FlyBaseID: FBgn0038853
• Length: 1330
• Species: Drosophila melanogaster
• Sequence 2: NP_775145.2
• Gene: Arhgap39 / 500901
• RGDID: 1593158
• Length: 1109
• Species: Rattus norvegicus
• Alignment Length: 1398
• Identity: 425/1398 - (30%)
• Similarity: 594/1398 - (42%)
• Gaps: 385/1398 - (27%)

  Fly     4 SCERIEWVEIIEPRTKEHMYANLTTGECVWDPPEDVPIKRTDSSQWWELFDTNTQRFYYYNAATQ 68
            |..|:||||||||||:|.|||||.|||||||||..|.||||...|||||||.||.|||||:||:|
  Rat    26 SSTRLEWVEIIEPRTRERMYANLVTGECVWDPPAGVRIKRTSEDQWWELFDPNTSRFYYYSAASQ 90

  Fly    69 KTVWHRPSKCDIIPLAKLQTLKQNTDPSERREQTTPQKQQQQQVQHASQQQQHPSPMSGPNKKGR 133
            :||||||..||||||||||||||||:.......::|                           ||
  Rat    91 RTVWHRPQNCDIIPLAKLQTLKQNTESPRASADSSP---------------------------GR 128

  Fly   134 GQQRISGGNGTVASSEEKLTSSEVISSPRGRQSFRVSTGDSSRSMDMQQQHPQGYASRRSQDSCN 198
            |.:..|.|:......||:   ::.:....||.:..|::.:.:.|..     |.|....:..:...
  Rat   129 GSRDGSTGSSLEPEPEER---AQELPVRGGRATTLVTSKEETSSCS-----PPGVLLEKDYEVYR 185

  Fly   199 QYKESGKSSDSSLSSAHGYRRFNDSGVPVSGHPDNLRL-------GSLQKQQRGGGKDNGAFEML 256
            .|...|:......||.    |:|      ||:.:.:.:       ..|..|..|...||
  Rat   186 DYSADGQLLHYRTSSL----RWN------SGNKERMLIKVADREPSFLTPQGNGYPADN------ 234

  Fly   257 QESTSSHNLPHGSTSTSS--SYAGGSGYGDKYFDHQLLPNHLQGYSSKSSDIASPTHSIHTPQSQ 319
             :....|..|.||..:.:  ::...:. |..:|..:.....|:  .::.|...||.      ..|
  Rat   235 -QPVGHHRRPSGSQHSPNLQTFVPDND-GTVFFPERRPSPFLR--RAELSGNCSPL------LIQ 289

  Fly   320 KKKMSPDAAPAA-QYNYAQQQHQQRSAQRSGGGAAGTGAPAGKSYGGDREYKVSLARSGSFMSSS 383
            .:|.|.|:.|:: :|.|....:::...                      ||:..:..... |...
  Rat   290 PRKPSSDSQPSSPRYGYEPPLYEEPPV----------------------EYQAPIYDEPP-MDVQ 331

  Fly   384 INPAAAGHHSKSYRKSSAEAANGGAASDDSMHEKYFKSVENTPLSRRRHT-TNATKSGGGASGSN 447
            ..|      :..|:..|.:.:.|                      |:.|. ..|||
  Rat   332 FEP------NSPYQTGSPQRSPG----------------------RKPHPFLQATK--------- 359

  Fly   448 TATSTAGSGSSSHKKHSSDSSPQSPISPQTKSSRQAKTSATSTVPQLQHSPRLQEPSHSLDLLSL 512
                                  |:|.||..:..| .|.........|::||..:|  :...|:.:
  Rat   360 ----------------------QTPTSPCQQLMR-TKQKCPERFLSLEYSPVGKE--YVRQLVYV 399

  Fly   513 ERISLG---KSGP-----ISPGGGTENLGLLTHSSRGSNDSARQRQKSNNSSANRSQSHHYPGQS 569
            |:....   ::||     .:|||||.:|                                .|...
  Rat   400 EQAGSSPKLRAGPRHKYAPNPGGGTYSL--------------------------------QPSPC 432

  Fly   570 SLRHSASSSLDKRGYHVGGGSGDGRGVTGGEKRRSKQHHYQQQADNSDVEYDNGNTSPLYTNWDQ 634
            .||       |:|   :|..|||...:.|.|.|.|:......||....:.:.:
  Rat   433 LLR-------DQR---LGVRSGDYSTMEGPESRSSQPPTPLPQAQEDAMSWSS------------ 475

  Fly   635 EMPHLLPLKHYIIEQAKLSGRYEYRGGDGGDSDSYHSDSQSEHSLSGHEPDNEDSDGGSDTHGGY 699
                         :|..:|..        |.|.........:.||. ..|....:||..|.
  Rat   476 -------------QQDTMSST--------GYSPGTRKRKNRKPSLC-QVPSTSSTDGAGDL---- 514

  Fly   700 LEHNYGMIDDYANMGDSVSYYAYMYPPHDPAGREDISENVEAVLEGIGGNATEPSAPTATAPKPK 764
                         :||.                                ..||..:|..::..|.
  Rat   515 -------------LGDQ--------------------------------PLTEERSPCRSSLTPV 534

  Fly   765 PRYQISYYDTVSHSP-----SAGSGYHGQQLYSNTPPYSGHGHGHHVPPPSLPHQQQLHLEPSDT 824
            .    :..|.|..:|     .|...:..||           .|.|.....|...||    :.|..
  Rat   535 K----AETDLVRGTPEPFLAQARLAWEAQQ-----------AHFHMKQRGSWDSQQ----DGSGY 580

  Fly   825 KQKQSQTLPSPN---RQISRLAGAGHQGSGP-AASSKEETGHSTVAGQQQVTVGTVTPASLSRPG 885
            :...:..||.|.   |..|.......|.|.. ..|:.|:.|...:..::.::|.|    :|:.|.
  Rat   581 ESDGAVPLPMPGPVVRAFSEDEALAQQDSKHWKRSTFEKLGFPQILLEKSISVQT----NLASPE 641

  Fly   886 HKMAPP------------------SLKPTIQQIFPP-SERAPGMGNLGLGGPTLACMKECDIEKF 931
            ..:.|.                  |..|:...:||. :.|.|.              .|.|||.:
  Rat   642 PYLHPSQSEDLGACAQFENSRQNRSAVPSSSCVFPTFTLRKPS--------------SETDIENW 692

  Fly   932 AADNLNLHSKGIFRKKASVRDMLSWTAEAISRPMLALSRDKADKKTAIELFKLVQIYMADRKARI 996
            |:.:.|.|::|:||:|.|:.:||:|::|:|.:||:..| |:..||.|.|:|||:|:||.||:|:.
  Rat   693 ASKHFNKHTQGLFRRKVSIANMLAWSSESIKKPMIVTS-DRHVKKEACEIFKLIQMYMGDRRAKA 756

  Fly   997 GMTLNSVAIEIISASLPQQQLRDELYVQLCRQTTENPKRDSLIRGWELMAICLSYVPPSPTFQPT 1061
            ...  .||:||.:.....|.||||||:|||||||||.:.:||.||||||||||::.||:|.|...
  Rat   757 DPL--HVALEIATKGWSAQGLRDELYIQLCRQTTENFRLESLARGWELMAICLAFFPPTPKFHSY 819

  Fly  1062 LLNYVNRHRDPSFATCFMEVSK----------------------WPIHVQISHYATVCCRRLDRI 1104
            |..|:.||.||...|...:..|                      .|..|.||.||..|..:|.:.
  Rat   820 LEGYIYRHMDPVNDTKVTQHIKELLERNSKKKSKLRKKPKPYVEEPDGVAISTYAKYCYHKLQKA 884

  Fly  1105 GSSG-RRMAKKPTVDEVEQARQQILRNSMFGNTLSEVMDLQKEKFPFRKLPWIQTTLSEHVLLLN 1168
            ..:| ::..|||.|:|:..|:..:...||||:.|.|||.:|||::|.|:|||:||.|||.||.||
  Rat   885 ALTGAKKGLKKPNVEEIRHAKNAVFSPSMFGSALQEVMSMQKERYPDRQLPWVQTRLSEEVLALN 949

  Fly  1169 GKQTEGIFRVSADVDEVGCMKNRLDRWDVPDYKNTLVDAHTPASLLKLWYRELYDPLIPDAYYED 1233
            |.||||||||..|:|||..:|.::|:|.||   ..|.|.|.||||||||||||.:||||..:||.
  Rat   950 GDQTEGIFRVPGDIDEVNALKLQVDQWKVP---TGLEDPHVPASLLKLWYRELEEPLIPHEFYEQ 1011

  Fly  1234 CV-NTEDPDKAKEIVNKLPEINQLVLTYLIHFLQQFAIPEVVSCTKMDSSNLAMVFAPNCLRCTS 1297
            |: :.|.|:.|..:|:.||.||::||.|||.|||.|..|..|:.||||.||||||.|||||||.|
  Rat  1012 CIAHYESPEAAVAVVHALPRINRMVLCYLIRFLQVFVQPANVAITKMDVSNLAMVMAPNCLRCQS 1076

  Fly  1298 EDPKVILENARKEMSFMRTLIQHMDTTHVANLV 1330
            :||:||.||.||||||:|.||||:||:.:..::
  Rat  1077 DDPRVIFENTRKEMSFLRVLIQHLDTSFMEGVL 1109

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP93B	NP_650939.2	WW	50..75	CDD:278809	19/24 (79%)
		MyTH4	956..1122	CDD:295320	78/188 (41%)
		RhoGAP_KIAA1688	1133..1320	CDD:239854	115/187 (61%)
Arhgap39	NP_775145.2	PRK10263	<219..>378	CDD:236669	40/257 (16%)
		MyTH4	762..903	CDD:395633	57/140 (41%)
		RhoGAP_KIAA1688	914..1099	CDD:239854	115/187 (61%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351879
Domainoid	1	1.000	46	1.000	Domainoid score	I11820
eggNOG	1	0.900	-	-		E1_28IV8
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1123653at2759
OrthoFinder	1	1.000	-	-		FOG0003397
OrthoInspector	1	1.000	-	-		oto96082
orthoMCL	1	0.900	-	-		OOG6_103785
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.610