DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP93B and Arhgap25

DIOPT Version :9

Sequence 1:	NP_650939.2	Gene:	RhoGAP93B / 42496	FlyBaseID:	FBgn0038853	Length:	1330	Species:	Drosophila melanogaster
Sequence 2:	NP_001102717.1	Gene:	Arhgap25 / 500246	RGDID:	1562105	Length:	648	Species:	Rattus norvegicus

Alignment Length:	355	Identity:	88/355 - (24%)
Similarity:	146/355 - (41%)	Gaps:	55/355 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly  1002 SVAIEIISASLPQQQLRDELYVQLCRQTTENP-----------KRDSLIRGWE-----LMAICLS 1050
            ::.:|.:..:..:..:..|........||.||           |:.|:::.|:     |.|..|.
  Rat    12 NLKVETVKIARSRSVMTGEQMAAFHPPTTPNPLERPIKMGWLKKQRSIVKNWQQRYFVLKARQLY 76

  Fly  1051 YVPPSPTFQPTLLNYVNRHRDPSFATCFMEVSKWPIHV-----------QISHYATVCCR-RLDR 1103
            |.......:|....|:........||...|..|:...|           |.|:......: .::.
  Rat    77 YYKDEEDSKPQGCMYLPGSTVKEIATNPEEAGKFVFEVIPASSDQNRTGQDSYVLMASSQVEMEE 141

  Fly  1104 IGSSGRRMAKKPTVDEVEQARQQILRNSMFGNTLSEVMDLQKEKFPFRKLPWIQTTLSEHVLLLN 1168
            .....||:|..|:             .::||..|.|.: ..::||....:|.:....||.: |.:
  Rat   142 WVKFLRRVAGTPS-------------GAVFGQRLDETV-AYEQKFGPHLVPILVEKCSEFI-LEH 191

  Fly  1169 GKQTEGIFRVSADVDEVGCMKNRLDRWDVPDYKNTLVDAHTPASLLKLWYRELYDPLIPDAYYED 1233
            |...|||||:....:.|..:::..|..:.|.:... .|.||.||||||:.|:|.:|::|.:.||.
  Rat   192 GVSEEGIFRLPGQDNLVKQLRDAFDAGERPSFDRD-TDVHTVASLLKLYLRDLPEPVVPWSQYEG 255

  Fly  1234 ---C--VNTEDPDKAKEIVNK----LPEINQLVLTYLIHFLQQFAIPEVVSCTKMDSSNLAMVFA 1289
               |  :...|..||::.:.|    ||..|..:|:|:..||.:..:...|:  ||...|||.|..
  Rat   256 FLLCGQLTNADEAKAQQELEKQLSILPRDNYNLLSYICRFLHEIQLNCAVN--KMSVDNLATVIG 318

  Fly  1290 PNCLRCTSEDPKVILENARKEMSFMRTLIQ 1319
            .|.:|...|||.||:....:....|..:|:
  Rat   319 VNLIRSKVEDPAVIMRGTPQIQRVMTMMIR 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP93B	NP_650939.2	WW	50..75	CDD:278809
		MyTH4	956..1122	CDD:295320	26/147 (18%)
		RhoGAP_KIAA1688	1133..1320	CDD:239854	62/196 (32%)
Arhgap25	NP_001102717.1	PH_RhoGap25-like	45..157	CDD:270083	20/124 (16%)
		PH	47..149	CDD:278594	17/101 (17%)
		RhoGAP_ARHGAP22_24_25	156..354	CDD:239855	62/198 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910