Protein Alignment RhoGAP93B and RhoGAP93B

DIOPT Version :10

• Sequence 1: NP_650939.2
• Gene: RhoGAP93B / 42496
• FlyBaseID: FBgn0038853
• Length: 1330
• Species: Drosophila melanogaster
• Sequence 2: XP_061506230.1
• Gene: RhoGAP93B / 3291029
• VectorBaseID: AGAMI1_014818
• Length: 1446
• Species: Anopheles gambiae
• Alignment Length: 1564
• Identity: 708/1564 - (45%)
• Similarity: 860/1564 - (54%)
• Gaps: 352/1564 - (22%)

  Fly     1 MSSSCERIEWVEIIEPRTKEHMYANLTTGECVWDPPEDVPIKRTDSSQWWELFDTNTQRFYYYNA 65
            ||:|.||:|||||||||||||||||||||||||||||.|.|||||:|||||||||||.||||||.
Mosquito     1 MSTSSERVEWVEIIEPRTKEHMYANLTTGECVWDPPEGVTIKRTDASQWWELFDTNTCRFYYYNV 65

  Fly    66 ATQKTVWHRPSKCDIIPLAKLQTLKQNTDPSERREQTTPQKQQQQQVQHASQQQQHPSPMSGPNK 130
            |:||||||||..|||||||||||||||||||:|::.|.|        .|......|.:..||...
Mosquito    66 ASQKTVWHRPQNCDIIPLAKLQTLKQNTDPSDRKDATLP--------HHHHHHHHHGTGSSGSTA 122

  Fly   131 KG-------RGQQRISGGNGTVASS---------------------------------EEKLTSS 155
            .|       .|..:: ||:|||..|                                 .::.::|
Mosquito   123 GGIGGLGSLGGASKL-GGSGTVGKSCGHRTATGVTDYRDRDHHHRSSSSGHRRGGGGGLDQRSNS 186

  Fly   156 EVISSPRGRQSFR-----------VSTGDSSRSMDMQQQH----------PQGYASRRSQDSCNQ 199
            |:::||:||.|.:           ::.|.|..|:.....|          |...:.|.||.....
Mosquito   187 ELLASPQGRHSLQHRLPPKILTSPLADGSSHSSISRLDSHKFCRHGGMSVPSSGSVRGSQRYPAS 251

  Fly   200 YKESGKSS--------------DSSLSSAHG------YRRFND---SGVPVSGHPDNLRLGSLQK 241
            |:.|...:              ||||.|..|      |||.:.   ..||.:.....||.||...
Mosquito   252 YQHSHLHASQQHHQRFHHHHHPDSSLKSPEGGSLSGSYRRLHGGVVGSVPEATGSSLLRYGSGSS 316

  Fly   242 QQRGGGKDNG-------------AFEMLQESTSSHNLPHG------STSTSSSYAGGS----GYG 283
            .....|...|             .:.|||||:||||:||.      |:||::..|..|    ..|
Mosquito   317 GYATNGHSTGGTGSRKHNPDSSSGYRMLQESSSSHNIPHSVVVPSPSSSTAAVSAVSSSEKLALG 381

  Fly   284 DKYFDHQLLPNH-LQGYS-SKSSDIA-----SPTHSIHTPQSQKKKMSPDAAPAAQYNYAQQQHQ 341
            ..:....|.|.| :..|| |.|||:|     ||:||:.|||.:||.|.......:         .
Mosquito   382 ALHHSSALPPPHQMLSYSISNSSDLAAGSLSSPSHSLSTPQFKKKFMHDGGVGGS---------S 437

  Fly   342 QRSAQRSGGGAAG-TGAPAGKSYGGD-REYKVSLARSGSFMSSS------------------INP 386
            .:|..:.|..|.| ........|||: ....:||.|||||:||:                  ..|
Mosquito   438 SKSTSKDGNLAGGMVSKHESFDYGGNPSASSISLTRSGSFLSSAGITSGVGGVLGTPISSRPYGP 502

  Fly   387 AAAG--HHSK--SYRKSSAE-----------------------AANGGAASDDSMHEKYFKSVEN 424
            :.:|  |||.  |:||.|.:                       |..||..|||||||||||||||
Mosquito   503 SGSGGSHHSSSGSHRKGSFDGNGGSGNVPGSGAGGNVGGSGTAAGGGGGGSDDSMHEKYFKSVEN 567

  Fly   425 TPLSRRRHTTNATKSGGGASGSNTATSTAGSGSSSHKKHSSDSSPQSPISPQ------------- 476
            ||::||||||::                  ......:|.|||||||||||||
Mosquito   568 TPITRRRHTTSS------------------KSPLQQQKQSSDSSPQSPISPQQQQQVKVQRPSAL 614

  Fly   477 ---------------TKSS-RQAKTSATSTVPQLQHSPRLQEPSHSLDLLS------LERISLGK 519
                           .||| :.:.|::::|.......|      :|:|.|.      .|::...:
Mosquito   615 SVELSPGSSYQNNGSNKSSHKNSNTNSSNTTGDHPSEP------YSVDGLKGKADKYQEKMKQDR 673

  Fly   520 SGPISPG----GGTE--------------------NLGLLTHSSRGSNDSARQRQKSNNSSANRS 560
            :|.||||    ||.:                    |.|..:..|.|.:..:....:||....||.
Mosquito   674 AGKISPGAVSVGGKQSPYPPNIPASSSSSHPVDQTNSGSTSKGSAGKDHFSLNLNQSNLDRHNRQ 738

  Fly   561 QSHHYPGQSSLRHSASSSLDKRGYHVGGGSGDGRGVTGGEKRRSKQHHYQQQADNSDVEYDNGNT 625
            ..   |.|:..:.|:.|:     :.|...:........|:|.::..:|........|.:||||||
Mosquito   739 LD---PQQTLEKKSSGST-----HTVASNNSSSHNAKHGKKSKNYSNHNTAGGTGFDFDYDNGNT 795

  Fly   626 SPLYTNWDQEM-PHLLPLKHYIIEQAKLSGRYEYRGGDGG-DSDSYHSDSQSEHSLSGHEPDNED 688
            ||||.|||:|| .|||||:|||:|||||||.|    |.|. ||||:|||||||||.|||||||||
Mosquito   796 SPLYCNWDKEMQEHLLPLQHYILEQAKLSGSY----GLGDLDSDSFHSDSQSEHSFSGHEPDNED 856

  Fly   689 SDGGSDTHGGYLEH----NYGMIDDYANMGDSVSYYAYMYPPHDPAGREDISENVEAVLEGIGGN 749
            || .||.||.||.|    .||.  .:|..| .||||.:.:...|...:|||||.|.|.||
Mosquito   857 SD-HSDGHGDYLAHYPYEEYGA--RHAQDG-GVSYYNFEFNFGDRDEKEDISEEVTAKLE----- 912

  Fly   750 ATEPSAPTATAPKPKPRYQISYYDTVSHSPSAGSGYHGQQLYSNTPPYSGHGHGHHVPPPSLPHQ 814
                |.|                               .|:||   |...|...|..||.:....
Mosquito   913 ----SMP-------------------------------DQIYS---PVKNHPPLHKFPPAAFQGA 939

  Fly   815 QQLHLEPS----DTKQKQSQTLPSPNRQISRLAGAGHQGSGPAASSKEE----TGHSTVAGQQQV 871
            :.. |:.|    |...:...|:|         .|..:...|...|..::    .||     .||:
Mosquito   940 RSA-LDASGLVPDAVDRGVPTVP---------MGGANSTFGSKTSYLQQMAAAAGH-----HQQL 989

  Fly   872 TVGTVTPASLSRPGHKMAPPSLKPTIQQIFPPSERAPGMGNLGLGGPTLACMKECDIEKFAADNL 936
            .:|....:...:|.||:...:|....|:.......|||:|..|... .:|.:|||||||||.|||
Mosquito   990 QLGGAMQSPQQQPPHKINKATLLQRFQENLSLGASAPGVGGNGKIA-EMALLKECDIEKFAQDNL 1053

  Fly   937 NLHSKGIFRKKASVRDMLSWTAEAISRPMLALSRDKADKKTAIELFKLVQIYMADRKARIGMTLN 1001
            |||||||||||:|||||||||:.|||||||:|:||||.||.|.:|||||||||.||||||||:||
Mosquito  1054 NLHSKGIFRKKSSVRDMLSWTSNAISRPMLSLARDKAGKKMATDLFKLVQIYMGDRKARIGMSLN 1118

  Fly  1002 SVAIEIISASLPQQQLRDELYVQLCRQTTENPKRDSLIRGWELMAICLSYVPPSPTFQPTLLNYV 1066
            ||||:|::.::.|.|||||||:|:||||||||.||||||||||||||||:|||||||||.||.|:
Mosquito  1119 SVAIDIVTMAMGQAQLRDELYIQMCRQTTENPSRDSLIRGWELMAICLSFVPPSPTFQPALLGYI 1183

  Fly  1067 NRHRDPSFATCFMEVSKWPIHVQISHYATVCCRRLDRIGSSGRRMAKKPTVDEVEQARQQILRNS 1131
            ||||||||||.|.||.|||||||||||||:.||||||||||||:.||:||.||:.|||:||.|:|
Mosquito  1184 NRHRDPSFATSFPEVGKWPIHVQISHYATIACRRLDRIGSSGRKQAKRPTEDEINQAREQIFRDS 1248

  Fly  1132 MFGNTLSEVMDLQKEKFPFRKLPWIQTTLSEHVLLLNGKQTEGIFRVSADVDEVGCMKNRLDRWD 1196
            ||||||||||:||||:||.|:||||||||||.|||||||||||||||.||||||..:||.:|||:
Mosquito  1249 MFGNTLSEVMELQKERFPDRQLPWIQTTLSEQVLLLNGKQTEGIFRVPADVDEVNMLKNLIDRWE 1313

  Fly  1197 VPDYKNTLVDAHTPASLLKLWYRELYDPLIPDAYYEDCVNTEDPDKAKEIVNKLPEINQLVLTYL 1261
            .|:.|.|: |||.|||||||||||||||||||..|::||.||||.:|..||.|||:||:||||||
Mosquito  1314 FPENKGTM-DAHAPASLLKLWYRELYDPLIPDELYDECVQTEDPAEAAAIVEKLPKINRLVLTYL 1377

  Fly  1262 IHFLQQFAIPEVVSCTKMDSSNLAMVFAPNCLRCTSEDPKVILENARKEMSFMRTLIQHMDTTHV 1326
            |||||||::|:||:.|||||||||||||||.|||.|:|||||||||||||:|||||||||||:.|
Mosquito  1378 IHFLQQFSLPDVVANTKMDSSNLAMVFAPNLLRCQSQDPKVILENARKEMTFMRTLIQHMDTSSV 1442

  Fly  1327 ANLV 1330
            ..||
Mosquito  1443 TYLV 1446

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP93B	NP_650939.2	PRP40	1..>75	CDD:227435	64/73 (88%)
		PAT1	<737..>892	CDD:401645	31/162 (19%)
		MyTH4	1004..1122	CDD:459939	92/117 (79%)
		RhoGAP_KIAA1688	1133..1320	CDD:239854	146/186 (78%)
RhoGAP93B	XP_061506230.1	None