DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP93B and Arhgap25

DIOPT Version :9

Sequence 1:	NP_650939.2	Gene:	RhoGAP93B / 42496	FlyBaseID:	FBgn0038853	Length:	1330	Species:	Drosophila melanogaster
Sequence 2:	NP_001032816.1	Gene:	Arhgap25 / 232201	MGIID:	2443687	Length:	648	Species:	Mus musculus

Alignment Length:	323	Identity:	87/323 - (26%)
Similarity:	137/323 - (42%)	Gaps:	45/323 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly  1029 TTENP-----------KRDSLIRGWE-----LMAICLSYVPPSPTFQPTLLNYVNRHRDPSFATC 1077
            ||.||           |:.|:::.|:     |.|..|.|.......:|....|:........||.
Mouse    39 TTPNPLERPIKVGWLKKQRSIVKNWQQRYFVLRAQQLYYYKDEEDSKPQGCMYLPGSTVKEIATN 103

  Fly  1078 FMEVSKWPIHVQISHYATVCCRRLDRIGSSGRRMAKKPTVDEVEQARQQILR-------NSMFGN 1135
            ..|..|:...|      .......:|||.....:.....|:..|..:  .||       .::||.
Mouse   104 PEEAGKFVFEV------IPASSDQNRIGQDSYVLMASSQVEMEEWVK--FLRRVAGTPSGAVFGQ 160

  Fly  1136 TLSEVMDLQKEKFPFRKLPWIQTTLSEHVLLLNGKQTEGIFRVSADVDEVGCMKNRLDRWDVPDY 1200
            .|.|.: ..::||....:|.:....:|.: |.:|...|||||:....:.|..:::..|..:.|.:
Mouse   161 RLDETV-AYEQKFGPHLVPILVEKCAEFI-LEHGVSEEGIFRLPGQDNLVKQLRDAFDAGERPSF 223

  Fly  1201 KNTLVDAHTPASLLKLWYRELYDPLIPDAYYED---CVNTEDPDKAK---EIVNK---LPEINQL 1256
            ... .|.||.||||||:.|:|.:|::|.:.||.   |....:.|:||   |:|.:   ||..|..
Mouse   224 DRD-TDVHTVASLLKLYLRDLPEPVVPWSQYEGFLLCGQLMNADEAKAQQELVKQLSTLPRDNYN 287

  Fly  1257 VLTYLIHFLQQFAIPEVVSCTKMDSSNLAMVFAPNCLRCTSEDPKVILENARKEMSFMRTLIQ 1319
            :|:|:..||.:..:...|:  ||...|||.|...|.:|...|||.||:....:....|..:|:
Mouse   288 LLSYICRFLHEIQLNCAVN--KMSVDNLATVIGVNLIRSKVEDPAVIMRGTPQIQRVMTMMIR 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP93B	NP_650939.2	WW	50..75	CDD:278809
		MyTH4	956..1122	CDD:295320	22/108 (20%)
		RhoGAP_KIAA1688	1133..1320	CDD:239854	62/196 (32%)
Arhgap25	NP_001032816.1	PH_RhoGap25-like	45..157	CDD:270083	21/119 (18%)
		PH	47..149	CDD:278594	21/109 (19%)
		RhoGAP_ARHGAP22_24_25	156..354	CDD:239855	62/198 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	356..559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910