DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP93B and arhgap24

DIOPT Version :9

Sequence 1:	NP_650939.2	Gene:	RhoGAP93B / 42496	FlyBaseID:	FBgn0038853	Length:	1330	Species:	Drosophila melanogaster
Sequence 2:	XP_001339010.2	Gene:	arhgap24 / 100005116	ZFINID:	ZDB-GENE-091118-20	Length:	752	Species:	Danio rerio

Alignment Length:	236	Identity:	71/236 - (30%)
Similarity:	107/236 - (45%)	Gaps:	32/236 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly  1118 DEVEQARQQI---LRNSMFGNTLSEVMDLQKEKFPFRKLPWIQTTLSEHVLLLN-GKQTEGIFRV 1178
            |.|:..|:.|   ....:||..|.|.:..:: ::..:..|.:.....:  .:.| |.:.||:||:
Zfish   118 DWVKSIRRVIWAPFGGGIFGQKLEETVRYER-RYGNKMAPMLVEQCVD--FIRNWGLREEGLFRL 179

  Fly  1179 SADVDEVGCMKNRLDRWDVPDYK-NTLVDAHTPASLLKLWYRELYDPLIPDAYYED---CVNTED 1239
            ....:.|..:::..|..:.|.:. ||  |.||.||||||:.|||.:|:||.:.||:   |.....
Zfish   180 PGQANLVKELQDAFDCGEKPSFDCNT--DVHTVASLLKLYLRELPEPVIPFSKYEEFLACTKLLS 242

  Fly  1240 PDK---AKEI---VNKLPEINQLVLTYLIHFLQQFAIPEVVSCTKMDSSNLAMVFAPNCLRCTSE 1298
            .|:   .||:   |..||.:|..:|.|:..||.:  :.......||...|||.||.||.||...|
Zfish   243 KDQEAGMKELRRQVEALPVVNYNLLKYICKFLDE--VQSYSGVNKMSVQNLATVFGPNILRPKVE 305

  Fly  1299 DPKVILENARKEMSFMRTLI-----------QHMDTTHVAN 1328
            ||..|:|........|..||           :|..|..:.|
Zfish   306 DPVTIMEGTVLVQQLMAVLIGQHDVLFPAEEEHSSTLELVN 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP93B	NP_650939.2	WW	50..75	CDD:278809
		MyTH4	956..1122	CDD:295320	2/3 (67%)
		RhoGAP_KIAA1688	1133..1320	CDD:239854	64/208 (31%)
arhgap24	XP_001339010.2	PH-like	21..134	CDD:302622	4/15 (27%)
		PH	23..127	CDD:278594	3/8 (38%)
		RhoGAP_ARHGAP22_24_25	134..332	CDD:239855	64/204 (31%)
		BAR	<649..737	CDD:299863
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910