Protein Alignment HHEX and NKX6-2

DIOPT Version :10

• Sequence 1: NP_650938.2
• Gene: HHEX / 42495
• FlyBaseID: FBgn0038852
• Length: 323
• Species: Drosophila melanogaster
• Sequence 2: NP_796374.2
• Gene: NKX6-2 / 84504
• HGNCID: 19321
• Length: 277
• Species: Homo sapiens
• Alignment Length: 302
• Identity: 79/302 - (26%)
• Similarity: 108/302 - (35%)
• Gaps: 86/302 - (28%)

  Fly    34 SQSPVAVTAGIAT------PHALAMP---KASLATGSSSAAPTPSPSSATNIYDLSREAAAAQYA 89
            |.:|:|....:|.      |:||..|   ||....|..:..|..:|...::|  |.|...||...
Human    12 SSAPLAALHNMAEMKTSLFPYALQGPAGFKAPALGGLGAQLPLGTPHGISDI--LGRPVGAAGGG 74

  Fly    90 -------MKSMDSSAVLAPTSLRFNPI------YPDPASLFYQQVLQLQKNPSLFMPHFQAAAVA 141
                   :..:.|||     .:.|.|.      ||.|       :.:|...|.:|.|
Human    75 LLGGLPRLNGLASSA-----GVYFGPAAAVARGYPKP-------LAELPGRPPIFWP-------- 119

  Fly   142 AAAAVQPTAYCDQYSPFTMDCEGFPNPASAAAALYCNAYPAASFYMSNFGVKRKGGQIRFTSQQT 206
              ..||...:.|         .....||.|...|..:.             |:|..:..|:.||.
Human   120 --GVVQGAPWRD---------PRLAGPAPAGGVLDKDG-------------KKKHSRPTFSGQQI 160

  Fly   207 KNLEARFASSKYLSPEERRHLALQLKLTDRQVKTWFQNRRAKWRRANLSKRSASAQGPIAGAAVG 271
            ..||..|..:|||:..||..||..|.:|:.|||.||||||.|||     ||.|        ..:.
Human   161 FALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWR-----KRHA--------VEMA 212

  Fly   272 SPSSASSSSVPVLNLGSGSRCGQQSDEEDRMYLSEDDEDDDE 313
            |......|....|.:|     |..::::|......|...|||
Human   213 SAKKKQDSDAEKLKVG-----GSDAEDDDEYNRPLDPNSDDE 249

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HHEX	NP_650938.2	Homeodomain	200..251	CDD:459649	26/50 (52%)
NKX6-2	NP_796374.2	Repressor domain. /evidence=ECO:0000250|UniProtKB:D3Z4R4	89..142		16/83 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	132..155		6/35 (17%)
		Homeodomain	147..205	CDD:459649	29/62 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	210..250		10/45 (22%)