Protein Alignment HHEX and lbx2

DIOPT Version :10

• Sequence 1: NP_650938.2
• Gene: HHEX / 42495
• FlyBaseID: FBgn0038852
• Length: 323
• Species: Drosophila melanogaster
• Sequence 2: NP_001007135.1
• Gene: lbx2 / 64276
• ZFINID: ZDB-GENE-001206-2
• Length: 257
• Species: Danio rerio
• Alignment Length: 151
• Identity: 51/151 - (33%)
• Similarity: 68/151 - (45%)
• Gaps: 46/151 - (30%)

  Fly   193 KRKGGQIRFTSQQTKNLEARFASSKYLSPEERRHLALQLKLTDRQVKTWFQNRRAKWRRANLSKR 257
            ||:..:..||:.|...||.||...|||||.:|..:|.||.||:.||.|||||||||.:| :|.:.
Zfish   125 KRRKSRTAFTNHQIYELEKRFLYQKYLSPADRDQIAQQLGLTNAQVITWFQNRRAKLKR-DLEEM 188

  Fly   258 SASAQ--------------------------GPIAGAAV--GSPSSASSSSVPVLNLGSGSRCGQ 294
            .|..:                          |||:.:..  ..|.|.|||.            ||
Zfish   189 KADVESLKKIPPQALQKLVSMEDMEDAHGGSGPISPSLSPRAFPQSPSSSR------------GQ 241

  Fly   295 QSDEEDRMYLSEDDEDDDEDE 315
            .:||     .||:||:.:.|:
Zfish   242 TTDE-----FSEEDEEIEVDD 257

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HHEX	NP_650938.2	Homeodomain	200..251	CDD:459649	29/50 (58%)
lbx2	NP_001007135.1	Required for convergent extension movement and hypaxial myogenesis during gastrulation. Required for the formation of thick and thin myofilaments. Required for myod1 expression in the pectoral fin bud. Required for continuous expression of cxcl12a in the posterior lateral mesoderm at the tail bud stage and in adaxial cells at the 10-somite stage. /evidence=ECO:0000269|PubMed:19216761, ECO:0000269|PubMed:22216300, ECO:0000269|PubMed:22406073	1..46
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..43
		Homeodomain	127..183	CDD:459649	29/55 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	206..257		16/67 (24%)