Protein Alignment HHEX and PITX3

DIOPT Version :10

• Sequence 1: NP_650938.2
• Gene: HHEX / 42495
• FlyBaseID: FBgn0038852
• Length: 323
• Species: Drosophila melanogaster
• Sequence 2: NP_005020.1
• Gene: PITX3 / 5309
• HGNCID: 9006
• Length: 302
• Species: Homo sapiens
• Alignment Length: 173
• Identity: 49/173 - (28%)
• Similarity: 71/173 - (41%)
• Gaps: 57/173 - (32%)

  Fly   162 CEGFPNPAS--AAAALYCNAYPAASFYMSNFGVKRKGGQIRFTSQQTKNLEARFASSKYLSPEER 224
            |:|..:..|  |:|:|     |..|....:...|::..:..|||||.:.|||.|..::|.....|
Human    33 CKGQEHSDSEKASASL-----PGGSPEDGSLKKKQRRQRTHFTSQQLQELEATFQRNRYPDMSTR 92

  Fly   225 RHLALQLKLTDRQVKTWFQNRRAKWRR------ANLSKRSASAQ--------------------- 262
            ..:|:...||:.:|:.||:|||||||:      |.|.|.|.:|.
Human    93 EEIAVWTNLTEARVRVWFKNRRAKWRKRERSQQAELCKGSFAAPLGGLVPPYEEVYPGYSYGNWP 157

  Fly   263 ----------------------GPIAGAAVGS-PSSASSSSVP 282
                                  ||:|...|.| |||.::|.||
Human   158 PKALAPPLAAKTFPFAFNSVNVGPLASQPVFSPPSSIAASMVP 200

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HHEX	NP_650938.2	Homeodomain	200..251	CDD:459649	23/50 (46%)
PITX3	NP_005020.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..71		10/42 (24%)
		Homeodomain	63..119	CDD:459649	23/55 (42%)
		OAR	258..275	CDD:461067
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	262..275
		Nuclear localization signal. /evidence=ECO:0000255	268..272