Protein Alignment HHEX and MSX1

DIOPT Version :10

• Sequence 1: NP_650938.2
• Gene: HHEX / 42495
• FlyBaseID: FBgn0038852
• Length: 323
• Species: Drosophila melanogaster
• Sequence 2: NP_002439.2
• Gene: MSX1 / 4487
• HGNCID: 7391
• Length: 303
• Species: Homo sapiens
• Alignment Length: 292
• Identity: 82/292 - (28%)
• Similarity: 109/292 - (37%)
• Gaps: 67/292 - (22%)

  Fly    37 PVAVTAGIATPHALAMPKASLATGSSSAAPTPSPSSATNIYDLSREAAAAQYAMKSMDSSAVLAP 101
            |....||.| |.|.|...|::......|.|..|||    :...|.||..|.:.......|| |||
Human    24 PAGGGAGQA-PSAAAATAAAMGADEEGAKPKVSPS----LLPFSVEALMADHRKPGAKESA-LAP 82

  Fly   102 T------SLRFNPIYPDPASLFYQQVLQLQKNPSLFMP--HF---------QAAAVAAAAAVQPT 149
            :      .....|:...|.||.....      ||...|  ||         :.|.|.|.:..:|
Human    83 SEGVQAAGGSAQPLGVPPGSLGAPDA------PSSPRPLGHFSVGGLLKLPEDALVKAESPEKP- 140

  Fly   150 AYCDQYSPFTMDCEGFPNPASAAAALYCNAYPAASFYMSNFGVKRKGGQIRFTSQQTKNLEARFA 214
                :.:|:.......|.||...:...|.        :......|| .:..||:.|...||.:|.
Human   141 ----ERTPWMQSPRFSPPPARRLSPPACT--------LRKHKTNRK-PRTPFTTAQLLALERKFR 192

  Fly   215 SSKYLSPEERRHLALQLKLTDRQVKTWFQNRRAKWRR---ANLSKRSASAQ-------------- 262
            ..:|||..||...:..|.||:.|||.||||||||.:|   |.|.|...:|:
Human   193 QKQYLSIAERAEFSSSLSLTETQVKIWFQNRRAKAKRLQEAELEKLKMAAKPMLPPAAFGLSFPL 257

  Fly   263 -GPIAGAAVGSPSSASSS------SVPVLNLG 287
             ||.|.||....|...:|      ::||..:|
Human   258 GGPAAVAAAAGASLYGASGPFQRAALPVAPVG 289

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HHEX	NP_650938.2	Homeodomain	200..251	CDD:459649	25/50 (50%)
MSX1	NP_002439.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	18..55		10/31 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	69..117		12/54 (22%)
		PTZ00449	<105..>248	CDD:185628	46/162 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	133..174		7/53 (13%)
		Homeodomain	173..229	CDD:459649	27/56 (48%)