Protein Alignment HHEX and MEOX2

DIOPT Version :10

• Sequence 1: NP_650938.2
• Gene: HHEX / 42495
• FlyBaseID: FBgn0038852
• Length: 323
• Species: Drosophila melanogaster
• Sequence 2: NP_005915.2
• Gene: MEOX2 / 4223
• HGNCID: 7014
• Length: 304
• Species: Homo sapiens
• Alignment Length: 349
• Identity: 82/349 - (23%)
• Similarity: 121/349 - (34%)
• Gaps: 129/349 - (36%)

  Fly    44 IATPHALA-----MPKASLAT-GSSSAAPTPSPSSATNIYDLSREAAAAQYAMKSMDSSAVLAPT 102
            :.:|||.|     ..::|||. |.|.....|..|:::                    ||.::|.
Human     9 LRSPHATAQGLHPFSQSSLALHGRSDHMSYPELSTSS--------------------SSCIIAG- 52

  Fly   103 SLRFNPIYPDPASLF---------------------YQQVLQLQKN---PSLFMPHFQAAAVAAA 143
                   ||:...:|                     .||...||.|   |.:..|   .:|...:
Human    53 -------YPNEEGMFASQHHRGHHHHHHHHHHHHHQQQQHQALQTNWHLPQMSSP---PSAARHS 107

  Fly   144 AAVQPTAYCDQYSPFTMDCEGFPNPASAAAALYCNAY-------PAASFYMSNFG---------V 192
            ..:||            |..|.|...|:...|..|:.       ..|:....::|         .
Human   108 LCLQP------------DSGGPPELGSSPPVLCSNSSSLGSSTPTGAACAPGDYGRQALSPAEAE 160

  Fly   193 KRKGGQIR-------------------------FTSQQTKNLEARFASSKYLSPEERRHLALQLK 232
            ||.||:.:                         ||.:|.:.|||.||...||:...|..:|:.|.
Human   161 KRSGGKRKSDSSDSQEGNYKSEVNSKPRKERTAFTKEQIRELEAEFAHHNYLTRLRRYEIAVNLD 225

  Fly   233 LTDRQVKTWFQNRRAKWRRANLSKRSASA-QGPIAGAAVGS--PSSASSSSVPVLNLGSGSRCGQ 294
            ||:||||.||||||.||:|....::.|:| :..:.....|:  ||..|         |.|:...|
Human   226 LTERQVKVWFQNRRMKWKRVKGGQQGAAAREKELVNVKKGTLLPSELS---------GIGAATLQ 281

  Fly   295 QSDEEDRMYLSEDDEDDDEDEGEA 318
            |:.:.   ..:||..|.|.....|
Human   282 QTGDS---IANEDSHDSDHSSEHA 302

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HHEX	NP_650938.2	Homeodomain	200..251	CDD:459649	27/75 (36%)
MEOX2	NP_005915.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	63..192		22/143 (15%)
		COG5576	160..284	CDD:227863	42/132 (32%)
		Homeodomain	188..244	CDD:459649	27/55 (49%)