Protein Alignment HHEX and cdx4

DIOPT Version :10

• Sequence 1: NP_650938.2
• Gene: HHEX / 42495
• FlyBaseID: FBgn0038852
• Length: 323
• Species: Drosophila melanogaster
• Sequence 2: NP_989417.1
• Gene: cdx4 / 395056
• XenbaseID: XB-GENE-482787
• Length: 260
• Species: Xenopus tropicalis
• Alignment Length: 654
• Identity: 119/654 - (18%)
• Similarity: 196/654 - (29%)
• Gaps: 242/654 - (37%)

  Fly   378 ANAGVPST--STSSTSPPSSEYDYAYITAINTHQPLSVMRSAGGDEAPVSTTVLPDYCITTICCP 440
            |.|.:||.  .|.:.:.....|.|...|.:.|.:  |...:|.|..:|.::....|..::
 Frog    43 AAAPLPSPVWETHTDAGTGRPYYYNPDTGVTTWE--SPFEAAEGAASPATSPASVDSHVS----- 100

  Fly   441 IEVHEGYYSDDESEGT--------------------DHKLSMYRGQGGGGPG------------- 472
            :|...|.|.|:||...                    :.:|.|..|...|.||
 Frog   101 LETEWGQYWDEESRRVFFYNPLTGETAWEDEAENEPEEELEMQPGLSPGSPGDPRPPTPETDYPE 165

  Fly   473 -------------GS--------------GKLRH-----QQHHSNAEYTTERRQYLNSKGFLAYF 505
                         ||              |...|     |..::| .:|.|:...|.......||
 Frog   166 SLTSYPEEDYSPVGSFGEPGPTSPLTTPPGWSCHVSQDKQMLYTN-HFTQEQWVRLEDPHGKPYF 229

  Fly   506 VNLFQDTLAAEL-DIPAEDLRSATWKGAVVYSGQWEIVPAILSPWPREAIEW------VHRKRDV 563
            .|....::..|| .:|....||      :..|.|....||..|| |.|..:.      :||.:..
 Frog   230 YNPEDSSVRWELPQVPVPAPRS------IHKSSQDGDTPAQASP-PEEKTKTLDKAGVLHRTKTA 287

  Fly   564 KINPLTRQKFQWPTQPMI-----------QKVKSFGCHVIPS----------------GYAPKQG 601
            ......|:| .|.....:           .|..:.|....||                .:|||..
 Frog   288 DKGKRLRKK-HWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSKFSTPEYTVELRGATLSWAPKDK 351

  Fly   602 QNRHRQLEWKIVFPEAERYLESCLTGTQIKIYMITVLLLKTFVEPTLTPGLSMFGLEHLRAHL-- 664
            .:|...||.:            ...|::..|...:..::.|:.:....      |::.|.|.|
 Frog   352 SSRKNVLELR------------SRDGSEYLIQHDSEAIISTWHKAIAQ------GIQELSAELPP 398

  Fly   665 -----------------FWQ-----CETNYAAWPEDYLGEALLRFLNALLDRIKTHTLPDYFLPA 707
                             .||     ...|.||.....:|      |.:.|.::: |.|.. ||..
 Frog   399 EESESSRVDFGSSERLGSWQEKEEDARPNAAAPALGPVG------LESDLSKVR-HKLRK-FLQR 455

  Fly   708 RNLFENVPER-------------VLVELHK-RIFRITENPVMHLLIALRNLKLP-----SARLAF 753
            |...:::.|:             .|.|..: |:.|..:..:.  .:..|.|.:.     |..||.
 Frog   456 RPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIR--AVEARGLDIDGLYRISGNLAT 518

  Fly   754 YPKVRIKRLYSFLVIDNPLKIVNPMLRDEDENLAAEDSDENEANEREIAVGSMAYYHQQ------ 812
            ..|:|.|                   .|.||.|   |.|:....:..:..|::..:.::
 Frog   519 IQKLRYK-------------------VDHDERL---DLDDGRWEDVHVITGALKLFFRELPEPLF 561

  Fly   813 ------------EVESRRKRTRIVRFLVA--------------EQLKKERAVQPERRQSVESIDL 851
                        :::.:.:|:|.||.||.              :.|.:......:.|.||:|:.:
 Frog   562 PFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAI 626

  Fly   852 TFLP 855
            .|.|
 Frog   627 VFGP 630

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HHEX	NP_650938.2	Homeodomain	200..251	CDD:459649
cdx4	NP_989417.1	Caudal_act	16..147	CDD:461413	23/110 (21%)
		Homeodomain	154..209	CDD:459649	5/54 (9%)