Protein Alignment HHEX and PDX1

DIOPT Version :10

• Sequence 1: NP_650938.2
• Gene: HHEX / 42495
• FlyBaseID: FBgn0038852
• Length: 323
• Species: Drosophila melanogaster
• Sequence 2: NP_000200.1
• Gene: PDX1 / 3651
• HGNCID: 6107
• Length: 283
• Species: Homo sapiens
• Alignment Length: 266
• Identity: 71/266 - (26%)
• Similarity: 90/266 - (33%)
• Gaps: 56/266 - (21%)

  Fly    35 QSPVAVTAGIATPHALAMPKASLATGSSSAAPTPSPSSATNIYDLSREAAAAQYAMKSMDSSAVL 99
            :.|.|...|.| |...|.|.|.|..|.....|.|.|...         |..|.......|.|...
Human    15 KDPCAFQRGPA-PEFSASPPACLYMGRQPPPPPPHPFPG---------ALGALEQGSPPDISPYE 69

  Fly   100 APTSLRFNPIYPDPASLFYQQVLQLQKNPSLFMPHFQAAAVAAAAAVQPTAYCDQYSPFTMDCE- 163
            .|      |:..|||.......|..|    |.:||             |.|     .||....|
Human    70 VP------PLADDPAVAHLHHHLPAQ----LALPH-------------PPA-----GPFPEGAEP 106

  Fly   164 -----------GFPNPASAAAALYCNAYPAASFYMSNFGVKRKGGQIRFTSQQTKNLEARFASSK 217
                       .||...|..|..:...:...::.......||.  :..:|..|...||..|..:|
Human   107 GVLEEPNRVQLPFPWMKSTKAHAWKGQWAGGAYAAEPEENKRT--RTAYTRAQLLELEKEFLFNK 169

  Fly   218 YLSPEERRHLALQLKLTDRQVKTWFQNRRAKWRRANLSKRSASAQGPIAGAAVGSPSS--ASSSS 280
            |:|...|..||:.|.||:|.:|.||||||.||::....||....  .:.|..|..|..  |.:|.
Human   170 YISRPRRVELAVMLNLTERHIKIWFQNRRMKWKKEEDKKRGGGT--AVGGGGVAEPEQDCAVTSG 232

  Fly   281 VPVLNL 286
            ..:|.|
Human   233 EELLAL 238

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HHEX	NP_650938.2	Homeodomain	200..251	CDD:459649	24/50 (48%)
PDX1	NP_000200.1	Transactivation domain. /evidence=ECO:0000250	13..73		18/73 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	34..71		10/45 (22%)
		Antp-type hexapeptide	118..123		2/4 (50%)
		Homeodomain	147..203	CDD:459649	26/57 (46%)
		Nuclear localization signal. /evidence=ECO:0000250	197..203		4/5 (80%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	201..283		10/40 (25%)