Protein Alignment HHEX and BARHL2

DIOPT Version :10

• Sequence 1: NP_650938.2
• Gene: HHEX / 42495
• FlyBaseID: FBgn0038852
• Length: 323
• Species: Drosophila melanogaster
• Sequence 2: NP_064447.1
• Gene: BARHL2 / 343472
• HGNCID: 954
• Length: 387
• Species: Homo sapiens
• Alignment Length: 307
• Identity: 77/307 - (25%)
• Similarity: 106/307 - (34%)
• Gaps: 85/307 - (27%)

  Fly     7 SSKAAFSIENILEQKSSSHRSQSRRGSSQSPVAVTAGIATPHALAMPKASLATGSSSAAPTP--- 68
            :|.::|.|:.||...||.           ||     |:.......:.:|..|...|.|.|:|
Human     6 ASGSSFGIDTILSSASSG-----------SP-----GMMNGDFRPLGEARTADFRSQATPSPCSE 54

  Fly    69 ------SPSSATNIYDLSRE----AAAAQYAMKSMDSSAVLAPTSLRFNPIYPDPASLFYQQVLQ 123
                  :|||..::.....|    |.|.|:......|.....|.:.....:.|.|..   ||.|.
Human    55 IDTVGTAPSSPISVTMEPPEPHLVADATQHHHHLHHSQQPPPPAAAPTQSLQPLPQQ---QQPLP 116

  Fly   124 LQKNPSLFMPHFQAAAVAAAAAV--------------QPTAYCDQYSPFTMDCEGFPNPASAAAA 174
            .|:.|.  .|..|..:.|:|...              :|.|.|..||  |........|...:.|
Human   117 PQQPPP--PPPQQLGSAASAPRTSTSSFLIKDILGDSKPLAACAPYS--TSVSSPHHTPKQESNA 177

  Fly   175 LYCNAYPAASFYMSN---------------FGVKRKG--------------------GQIRFTSQ 204
            ::.:..|......|.               .|.|.:|                    .:..|:..
Human   178 VHESFRPKLEQEDSKTKLDKREDSQSDIKCHGTKEEGDREITSSRESPPVRAKKPRKARTAFSDH 242

  Fly   205 QTKNLEARFASSKYLSPEERRHLALQLKLTDRQVKTWFQNRRAKWRR 251
            |...||..|...||||.::|..||..|.|||.|||||:||||.||:|
Human   243 QLNQLERSFERQKYLSVQDRMDLAAALNLTDTQVKTWYQNRRTKWKR 289

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HHEX	NP_650938.2	Homeodomain	200..251	CDD:459649	27/50 (54%)
BARHL2	NP_064447.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..145		36/159 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	157..240		11/84 (13%)
		Homeodomain	233..289	CDD:459649	27/55 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	367..387