Protein Alignment HHEX and HMX3

DIOPT Version :10

• Sequence 1: NP_650938.2
• Gene: HHEX / 42495
• FlyBaseID: FBgn0038852
• Length: 323
• Species: Drosophila melanogaster
• Sequence 2: NP_001099044.1
• Gene: HMX3 / 340784
• HGNCID: 5019
• Length: 357
• Species: Homo sapiens
• Alignment Length: 336
• Identity: 88/336 - (26%)
• Similarity: 131/336 - (38%)
• Gaps: 94/336 - (27%)

  Fly     9 KAAFSIENILEQKSSSHRSQSRRGSSQSPVAVTAGIATPHALAMPKASLATGSSSAAPTPSPSSA 73
            ::.|||:|:|  ....||...:   .|.|         |..|..| ||.|..:::||
Human    28 ESPFSIKNLL--NGDHHRPPPK---PQPP---------PRTLFAP-ASAAAAAAAAA-------- 69

  Fly    74 TNIYDLSREAAAAQYAMKSMDSSAVLAPTSLRFNPIYPDPASLFYQQVLQLQKNPSLFMPHF--- 135
                     ||||:.|::.....|:.....|.| |.:..||..|......|:::|:.:.|:.
Human    70 ---------AAAAKGALEGAAGFALSQVGDLAF-PRFEIPAQRFALPAHYLERSPAWWYPYTLTP 124

  Fly   136 --------QAAAVAAAAAVQPTAYCDQYSPFTM----------------------------DCEG 164
                    :|:..|......|.:..|:.||..:                            ..||
Human   125 AGGHLPRPEASEKALLRDSSPASGTDRDSPEPLLKADPDHKELDSKSPDEIILEESDSEESKKEG 189

  Fly   165 FPNPASAAAAL-YCNAYPAASFYMSNF-------GVKRKGGQIRFTSQQTKNLEARFASSKYLSP 221
            ...|.:|.|:: ...|.|.|..:....       ..::|..:..|:..|...||:.|...:|||.
Human   190 EAAPGAAGASVGAAAATPGAEDWKKGAESPEKKPACRKKKTRTVFSRSQVFQLESTFDMKRYLSS 254

  Fly   222 EERRHLALQLKLTDRQVKTWFQNRRAKWRR--------ANLSKRSAS--AQGPIA----GAAVGS 272
            .||..||..|.||:.|||.||||||.||:|        ||||..:|.  .:.||.    .||.|:
Human   255 SERAGLAASLHLTETQVKIWFQNRRNKWKRQLAAELEAANLSHAAAQRIVRVPILYHENSAAEGA 319

  Fly   273 PSSASSSSVPV 283
            .::|:.:.|||
Human   320 AAAAAGAPVPV 330

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HHEX	NP_650938.2	Homeodomain	200..251	CDD:459649	26/50 (52%)
HMX3	NP_001099044.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..58		11/43 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	129..229		14/99 (14%)
		Homeodomain	228..284	CDD:459649	27/55 (49%)