Protein Alignment HHEX and HOXD13

DIOPT Version :10

• Sequence 1: NP_650938.2
• Gene: HHEX / 42495
• FlyBaseID: FBgn0038852
• Length: 323
• Species: Drosophila melanogaster
• Sequence 2: NP_000514.2
• Gene: HOXD13 / 3239
• HGNCID: 5136
• Length: 343
• Species: Homo sapiens
• Alignment Length: 314
• Identity: 79/314 - (25%)
• Similarity: 112/314 - (35%)
• Gaps: 120/314 - (38%)

  Fly    31 RGSSQSPV--------------AVTAGIATPHALAMPKASLATGSSSA----------------- 64
            ||...:||              |..|..|.....|.|..|..|||||:
Human    41 RGFLSAPVFAGTHSGRAAAAAAAAAAAAAAASGFAYPGTSERTGSSSSSSSSAVVAARPEAPPAK 105

  Fly    65 ---APTPSPSSAT--------------NIY---DLSREAAAAQYAMKS--------------MDS 95
               ||||:.::|.              |.|   .:|......|.|:||              ||.
Human   106 ECPAPTPAAAAAAPPSAPALGYGYHFGNGYYSCRMSHGVGLQQNALKSSPHASLGGFPVEKYMDV 170

  Fly    96 SAVLAPTSLRFNPIYPDPASL----FYQQVLQLQKNPSLFMPHFQAAAVAAAAAVQPTAYCDQYS 156
            |. ||.:|:..|.:   ||..    |||.    ..:|...:|                .|.|..|
Human   171 SG-LASSSVPANEV---PARAKEVSFYQG----YTSPYQHVP----------------GYIDMVS 211

  Fly   157 PF---------TMDCEGFPNPASA---AAALYCNA-YPAAS-FYMSNFG-----------VKRKG 196
            .|         .:..||:.:...|   .:.:||.. .|..| |:.|:|.           |.|:|
Human   212 TFGSGEPRHEAYISMEGYQSWTLANGWNSQVYCTKDQPQGSHFWKSSFPGDVALNQPDMCVYRRG 276

  Fly   197 GQIR--FTSQQTKNLEARFASSKYLSPEERRHLALQLKLTDRQVKTWFQNRRAK 248
            .:.|  :|..|.|.||..:|.:|:::.::||.::....|::|||..||||||.|
Human   277 RKKRVPYTKLQLKELENEYAINKFINKDKRRRISAATNLSERQVTIWFQNRRVK 330

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HHEX	NP_650938.2	Homeodomain	200..251	CDD:459649	21/51 (41%)
HOXD13	NP_000514.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..28
		polyalanine repeat	57..71		3/13 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	78..115		10/36 (28%)
		HoxA13_N	<100..172	CDD:463521	14/71 (20%)
		Homeodomain	277..333	CDD:459649	21/54 (39%)