Protein Alignment HHEX and HOXD8

DIOPT Version :10

• Sequence 1: NP_650938.2
• Gene: HHEX / 42495
• FlyBaseID: FBgn0038852
• Length: 323
• Species: Drosophila melanogaster
• Sequence 2: NP_062458.1
• Gene: HOXD8 / 3234
• HGNCID: 5139
• Length: 290
• Species: Homo sapiens
• Alignment Length: 300
• Identity: 71/300 - (23%)
• Similarity: 99/300 - (33%)
• Gaps: 108/300 - (36%)

  Fly    47 PHALAMPKASLATGSSSAAPTPS-PSSATNIYDLSREAAAAQYAMKSMDSSAV---LAPTSLRFN 107
            ||  |.|:|       .|.|.|| |.|.|...  .||....:|......|.|.   .||......
Human    62 PH--APPQA-------HAHPHPSPPPSGTGCG--GREGRGQEYFHPGGGSPAAAYQAAPPPPPHP 115

  Fly   108 PIYP------------DPASLFYQQVLQLQKNPSLFMPHFQAAAVAAAAAVQPTAYCDQYSPFTM 160
            |..|            :||..:....||.|       |.|         ..|..|...||.
Human   116 PPPPPPPPCGGIACHGEPAKFYGYDNLQRQ-------PIF---------TTQQEAELVQYP---- 160

  Fly   161 DCEGFP----------NPASAAAALYCNAYPAASFYMSNFGVKRKGGQIRFTSQQTKNLEARFAS 215
            ||:...          |.:|:.:.::....|.|:       ..|:.|:..::..||..||..|..
Human   161 DCKSSSGNIGEDPDHLNQSSSPSQMFPWMRPQAA-------PGRRRGRQTYSRFQTLELEKEFLF 218

  Fly   216 SKYLSPEERRHLALQLKLTDRQVKTWFQNRRAKWRRANLSKRSASAQGPIAGAAVGSPSSASSSS 280
            :.||:.:.|..::..|.||:||||.||||||.||::.|
Human   219 NPYLTRKRRIEVSHALALTERQVKIWFQNRRMKWKKEN--------------------------- 256

  Fly   281 VPVLNLGSGSRCGQQSDEEDRMYLSEDDEDDDEDEGEADE 320
                             .:|:..:|..:..|.|.:.||.|
Human   257 -----------------NKDKFPVSRQEVKDGETKKEAQE 279

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HHEX	NP_650938.2	Homeodomain	200..251	CDD:459649	23/50 (46%)
HOXD8	NP_062458.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	60..127		21/75 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	161..200		7/45 (16%)
		Homeodomain	198..254	CDD:459649	24/55 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	255..290		7/68 (10%)