Protein Alignment HHEX and HOXB9

DIOPT Version :10

• Sequence 1: NP_650938.2
• Gene: HHEX / 42495
• FlyBaseID: FBgn0038852
• Length: 323
• Species: Drosophila melanogaster
• Sequence 2: NP_076922.1
• Gene: HOXB9 / 3219
• HGNCID: 5120
• Length: 250
• Species: Homo sapiens
• Alignment Length: 279
• Identity: 68/279 - (24%)
• Similarity: 104/279 - (37%)
• Gaps: 77/279 - (27%)

  Fly    10 AAFSIENILEQKSSSHRSQ---------SRRGSSQSPVAVTAGIATPHALAMPKASLATGSSSAA 65
            :::.:::|:     ||.|:         .:..||:.| .....:..|.....|||.: .|:|.|.
Human     8 SSYYVDSII-----SHESEDAPPAKFPSGQYASSRQP-GHAEHLEFPSCSFQPKAPV-FGASWAP 65

  Fly    66 PTPSPS-SATNIYD-----------LSR------EAAAAQYAMKSMDSSAVLAPTSLRFNPIYPD 112
            .:|..| |..::|.           .||      |.|....|......:||.|      .|:...
Human    66 LSPHASGSLPSVYHPYIQPQGVPPAESRYLRTWLEPAPRGEAAPGQGQAAVKA------EPLLGA 124

  Fly   113 PASLFYQQVLQLQKNPSLFMPHFQAAAVAAAAAV---QPTAYCDQYSPFTMDCEGF-----PNPA 169
            |..|..|..           |.:.....|...||   |...|.|     ...|||.     |:..
Human   125 PGELLKQGT-----------PEYSLETSAGREAVLSNQRPGYGD-----NKICEGSEDKERPDQT 173

  Fly   170 SAAAALYCNAYPAASFYMSNFGVKRKGGQIRFTSQQTKNLEARFASSKYLSPEERRHLALQLKLT 234
            :          |:|::..:....|::   ..:|..||..||..|..:.||:.:.|..:|..|.|:
Human   174 N----------PSANWLHARSSRKKR---CPYTKYQTLELEKEFLFNMYLTRDRRHEVARLLNLS 225

  Fly   235 DRQVKTWFQNRRAKWRRAN 253
            :||||.||||||.|.::.|
Human   226 ERQVKIWFQNRRMKMKKMN 244

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HHEX	NP_650938.2	Homeodomain	200..251	CDD:459649	23/50 (46%)
HOXB9	NP_076922.1	Hox9_act	1..172	CDD:461369	41/192 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	21..47		3/26 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	149..182		9/47 (19%)
		Homeodomain	186..242	CDD:459649	24/58 (41%)