Protein Alignment HHEX and HOXB5

DIOPT Version :10

• Sequence 1: NP_650938.2
• Gene: HHEX / 42495
• FlyBaseID: FBgn0038852
• Length: 323
• Species: Drosophila melanogaster
• Sequence 2: NP_002138.1
• Gene: HOXB5 / 3215
• HGNCID: 5116
• Length: 269
• Species: Homo sapiens
• Alignment Length: 277
• Identity: 69/277 - (24%)
• Similarity: 104/277 - (37%)
• Gaps: 70/277 - (25%)

  Fly     1 MDIATKSSKAAFSIENILEQKSSSH------RSQSRRGSSQSPVAVTAGIATPHALAMPKASLAT 59
            ||::...|.|           ||||      .|::....:|.|....|  |:..:|:.|::...|
Human    52 MDLSVNRSSA-----------SSSHFGAVGESSRAFPAPAQEPRFRQA--ASSCSLSSPESLPCT 103

  Fly    60 GSSSAAPTPSPSSATNIYDLSREAAAAQYAMKSMDSSAVLAPTSLRFNPIYPDPASLFYQQVLQL 124
            ...|....||.||.::                    .|..|.:|..|..|....||...::....
Human   104 NGDSHGAKPSASSPSD--------------------QATSASSSANFTEIDEASASSEPEEAASQ 148

  Fly   125 QKNPSLFMPHFQAAAVAAAAAVQPTAYCDQYSPFTMDCEGFPNPASAAAALYCNAYPAASFYMSN 189
            ..:|||.....:..|.:.||   |.....|..|:                       ....::|:
Human   149 LSSPSLARAQPEPMATSTAA---PEGQTPQIFPW-----------------------MRKLHISH 187

  Fly   190 --FGVKRKGGQIRFTSQQTKNLEARFASSKYLSPEERRHLALQLKLTDRQVKTWFQNRRAKWRRA 252
              .|...|..:..:|..||..||..|..::||:...|..:|..|.|::||:|.||||||.||::.
Human   188 DMTGPDGKRARTAYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLSERQIKIWFQNRRMKWKKD 252

  Fly   253 NLSKRSASAQGPIAGAA 269
            |..|..:.|   .||:|
Human   253 NKLKSMSLA---TAGSA 266

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HHEX	NP_650938.2	Homeodomain	200..251	CDD:459649	23/50 (46%)
HOXB5	NP_002138.1	PRK07003	<67..>171	CDD:235906	27/128 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	77..173		26/120 (22%)
		Antp-type hexapeptide	176..181		1/27 (4%)
		Homeodomain	195..251	CDD:459649	24/55 (44%)