Protein Alignment HHEX and HOXA13

DIOPT Version :10

• Sequence 1: NP_650938.2
• Gene: HHEX / 42495
• FlyBaseID: FBgn0038852
• Length: 323
• Species: Drosophila melanogaster
• Sequence 2: NP_000513.2
• Gene: HOXA13 / 3209
• HGNCID: 5102
• Length: 388
• Species: Homo sapiens
• Alignment Length: 322
• Identity: 74/322 - (22%)
• Similarity: 118/322 - (36%)
• Gaps: 93/322 - (28%)

  Fly     4 ATKSSKAAFSIENILEQKSSSHRSQSRRGSSQSPVAVTAGIATPHALAMPKASLATGSSSAAPTP 68
            |..::.||....|::...:......:...||....|..:..|...|.|...|:.|..|||..|.|
Human    77 AAAAAAAANQCRNLMAHPAPLAPGAASAYSSAPGEAPPSAAAAAAAAAAAAAAAAAASSSGGPGP 141

  Fly    69 S-PSSATNIYDLSREAAAAQYAMKSMDSSAVLAPTSLRFNPIYPDPASLF---YQQVLQLQKNPS 129
            : |:.|......|..:||||       ||:  .|.:|        |...|   |....::..:|:
Human   142 AGPAGAEAAKQCSPCSAAAQ-------SSS--GPAAL--------PYGYFGSGYYPCARMGPHPN 189

  Fly   130 LFMPHFQAAAVAAAAAV-------------------------------------QP-TAYCD--- 153
            ......|.|:.|||||.                                     || ..|.|
Human   190 AIKSCAQPASAAAAAAFADKYMDTAGPAAEEFSSRAKEFAFYHQGYAAGPYHHHQPMPGYLDMPV 254

  Fly   154 ----------QYSPFTMDCEGF-----PNPASAAAALYC------------NAYPAASFYMSNFG 191
                      ::.|..:..|.:     ||..:  ..:||            :..|....:.|:..
Human   255 VPGLGGPGESRHEPLGLPMESYQPWALPNGWN--GQMYCPKEQAQPPHLWKSTLPDVVSHPSDAS 317

  Fly   192 VKRKGGQIR--FTSQQTKNLEARFASSKYLSPEERRHLALQLKLTDRQVKTWFQNRRAKWRR 251
            ..|:|.:.|  :|..|.|.||..:|::|:::.::||.::....|::|||..||||||.|.::
Human   318 SYRRGRKKRVPYTKVQLKELEREYATNKFITKDKRRRISATTNLSERQVTIWFQNRRVKEKK 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HHEX	NP_650938.2	Homeodomain	200..251	CDD:459649	21/52 (40%)
HOXA13	NP_000513.2	HoxA13_N	85..224	CDD:463521	36/155 (23%)
		Homeodomain	323..379	CDD:459649	21/55 (38%)