Protein Alignment HHEX and Nkx6-2

DIOPT Version :10

• Sequence 1: NP_650938.2
• Gene: HHEX / 42495
• FlyBaseID: FBgn0038852
• Length: 323
• Species: Drosophila melanogaster
• Sequence 2: NP_001101028.1
• Gene: Nkx6-2 / 309095
• RGDID: 1307280
• Length: 277
• Species: Rattus norvegicus
• Alignment Length: 328
• Identity: 87/328 - (26%)
• Similarity: 117/328 - (35%)
• Gaps: 111/328 - (33%)

  Fly     7 SSKAAFSIENILEQKSSSHRSQSRRGSSQSPVAV--TAGIATPHALAMPKASLATGSSSA-APTP 68
            ||....::.|:.|.|:|..           |.|:  .||..||          |.||..| .|..
  Rat    12 SSAPLAALHNMAEMKTSLF-----------PYALQGPAGFKTP----------ALGSLGAQLPLG 55

  Fly    69 SPSSATNIYDLSREAAAAQYA-------MKSMDSSAVLAPTSLRFNPI------YPDPASLFYQQ 120
            :|...::|  |.|...||...       :..:.|||     .:.|.|.      ||.|
  Rat    56 TPHGISDI--LGRPVGAAGGGLLGSLPRLNGLASSA-----GVYFGPAAAVARGYPKP------- 106

  Fly   121 VLQLQKNPSLFMPHFQAAAVAAAAAVQPTAYCDQYSPFTMDCEGFPNPASAAAALYCNAYPAASF 185
            :.:|...|.:|.|          ..||.:.:.|            |..|.:|.|
  Rat   107 LAELPGRPPIFWP----------GVVQGSPWRD------------PRLAGSAQA----------- 138

  Fly   186 YMSNFGV-----KRKGGQIRFTSQQTKNLEARFASSKYLSPEERRHLALQLKLTDRQVKTWFQNR 245
                .||     |:|..:..|:.||...||..|..:|||:..||..||..|.:|:.|||.|||||
  Rat   139 ----GGVLDKDGKKKHSRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNR 199

  Fly   246 RAKWRRANLSKRSASAQGPIAGAAVGSPSSASSSSVPVLNLGSGSRCGQQSDEEDRMYLSEDDED 310
            |.|||     ||.|        |.:.|......|....|.:|     |..::::|......|...
  Rat   200 RTKWR-----KRHA--------AEMASAKKKQDSDAEKLKVG-----GSDAEDDDEYNRPLDPNS 246

  Fly   311 DDE 313
            |||
  Rat   247 DDE 249

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HHEX	NP_650938.2	Homeodomain	200..251	CDD:459649	26/50 (52%)
Nkx6-2	NP_001101028.1	Homeodomain	147..205	CDD:459649	29/62 (47%)