Protein Alignment HHEX and en1a

DIOPT Version :10

• Sequence 1: NP_650938.2
• Gene: HHEX / 42495
• FlyBaseID: FBgn0038852
• Length: 323
• Species: Drosophila melanogaster
• Sequence 2: NP_571120.2
• Gene: en1a / 30244
• ZFINID: ZDB-GENE-980526-216
• Length: 231
• Species: Danio rerio
• Alignment Length: 262
• Identity: 58/262 - (22%)
• Similarity: 98/262 - (37%)
• Gaps: 93/262 - (35%)

  Fly    12 FSIENILEQKSSSHRSQSR--RGSSQSPVAVTAGIATPHALAMPKASLATGSSSAAPTPSPSSAT 74
            |.|:|||.......|.:.|  |.|...|.||         |......:::.:||...:|..||.:
Zfish    32 FFIDNILRPDFGCKRERERVTRDSGVRPTAV---------LDSRSDGVSSSASSTVSSPVSSSQS 87

  Fly    75 NIYDLSREAAAAQYAMKSMDSSAVLAPTSLRFNPIYPDPASLFYQQVLQLQKNPSLFMPHFQAAA 139
            |    ..|..:::.:..|.||.                      :|:|         .|.:
Zfish    88 N----KVEQGSSKSSSPSKDSQ----------------------KQIL---------WPAW---- 113

  Fly   140 VAAAAAVQPTAYCDQYSPFTMDCEGFPNPASAAAALYCNAYPAASFYMSNFGVKRKGG------- 197
                      .||.:||         ..|:|.....               .:|:|..
Zfish   114 ----------VYCTRYS---------DRPSSGPRTR---------------KLKKKNNNTESDDK 144

  Fly   198 --QIRFTSQQTKNLEARFASSKYLSPEERRHLALQLKLTDRQVKTWFQNRRAKWRRANLSKRSAS 260
              :..||::|.:.|:|.|.:|:|::.:.|:.||.:|.|.:.|:|.||||:|||.::::..|.:.:
Zfish   145 RPRTAFTAEQLQRLKAEFQTSRYITEQRRQALARELGLNESQIKIWFQNKRAKIKKSSGFKNALA 209

  Fly   261 AQ 262
            .|
Zfish   210 MQ 211

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HHEX	NP_650938.2	Homeodomain	200..251	CDD:459649	22/50 (44%)
en1a	NP_571120.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..29
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	43..105		17/74 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	121..148		4/41 (10%)
		Homeodomain	144..200	CDD:459649	22/55 (40%)
		Engrail_1_C_sig	201..230	CDD:431338	2/11 (18%)