Protein Alignment HHEX and RAX

DIOPT Version :10

• Sequence 1: NP_650938.2
• Gene: HHEX / 42495
• FlyBaseID: FBgn0038852
• Length: 323
• Species: Drosophila melanogaster
• Sequence 2: NP_038463.2
• Gene: RAX / 30062
• HGNCID: 18662
• Length: 346
• Species: Homo sapiens
• Alignment Length: 229
• Identity: 59/229 - (25%)
• Similarity: 80/229 - (34%)
• Gaps: 50/229 - (21%)

  Fly    68 PSPSSATNIYDLSREAAAAQYAMKSMDSSAVLAPTSLRFNPIYPDPASLFYQQVLQLQKNPSLFM 132
            |:...|....:..|...|.....|:.:..:..:|      |..|.||
Human    52 PAERGARGAKERDRRLGARPACPKAPEEGSEPSP------PPAPAPA------------------ 92

  Fly   133 PHFQAAAVAAAAAVQPTAYCDQYSPFTMDCEGFP-NPASAAAALYCNAYPAASFYMSNFGVKRKG 196
            |.::|          |..||.:.........|.| .||:..|.|.....|..         |.:.
Human    93 PEYEA----------PRPYCPKEPGEARPSPGLPVGPATGEAKLSEEEQPKK---------KHRR 138

  Fly   197 GQIRFTSQQTKNLEARFASSKYLSPEERRHLALQLKLTDRQVKTWFQNRRAKWRR-ANLSKRSAS 260
            .:..||:.|...||..|..|.|.....|..||.::.|.:.:|:.||||||||||| ..|...|..
Human   139 NRTTFTTYQLHELERAFEKSHYPDVYSREELAGKVNLPEVRVQVWFQNRRAKWRRQEKLEVSSMK 203

  Fly   261 AQ-GPIAGAAVGSPSSASSSSVPVLNLGSGSRCG 293
            .| .|:...:...||:..|.    |..|.||..|
Human   204 LQDSPLLSFSRSPPSATLSP----LGAGPGSGGG 233

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HHEX	NP_650938.2	Homeodomain	200..251	CDD:459649	22/50 (44%)
RAX	NP_038463.2	Octapeptide motif	33..40
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	46..145		24/135 (18%)
		Homeodomain	137..193	CDD:459649	22/55 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	194..318		12/44 (27%)
		OAR	319..335	CDD:461067
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	323..336
		Nuclear localization signal. /evidence=ECO:0000255	329..333