Protein Alignment HHEX and GBX1

DIOPT Version :10

• Sequence 1: NP_650938.2
• Gene: HHEX / 42495
• FlyBaseID: FBgn0038852
• Length: 323
• Species: Drosophila melanogaster
• Sequence 2: NP_001092304.1
• Gene: GBX1 / 2636
• HGNCID: 4185
• Length: 363
• Species: Homo sapiens
• Alignment Length: 371
• Identity: 96/371 - (25%)
• Similarity: 126/371 - (33%)
• Gaps: 149/371 - (40%)

  Fly    11 AFSIENILEQKSSSHRSQSRRGSSQSPVAVTAG--IATPHALAMPKASLATGSSSAAPTPSPSSA 73
            ||||::::                 .|....:|  :.|.:.:.||...|.. ..:.||.|.|:..
Human    24 AFSIDSLI-----------------GPPPPRSGHLLYTGYPMFMPYRPLVL-PQALAPAPLPAGL 70

  Fly    74 TNIYDLSREA--------AAAQYAMKSMDSSAVLAPTSLRFNPIYPDPASLFYQQVLQLQKNPSL 130
            ..:..|:..|        |....|:.||    |...|:|   |.:.:|...||.
Human    71 PPLAPLASFAGRLTNTFCAGLGQAVPSM----VALTTAL---PSFAEPPDAFYG----------- 117

  Fly   131 FMPHFQAAAVAAAAAVQPTAYCDQYSPFTMDCEG----------------------------FPN 167
              |...|||.|||||   ||..:...|.....||                            ||:
Human   118 --PQELAAAAAAAAA---TAARNNPEPGGRRPEGGLEADELLPAREKVAEPPPPPPPHFSETFPS 177

  Fly   168 -PA------SAAAALYCNA-YPAAS---------------FYMSN-------------------- 189
             ||      |....|..:| .||.|               |..|:
Human   178 LPAEGKVYSSDEEKLEASAGDPAGSEQEEEGSGGDSEDDGFLDSSAGGPGALLGPKPKLKGSLGT 242

  Fly   190 ---------FGVKRKGGQIR-----FTSQQTKNLEARFASSKYLSPEERRHLALQLKLTDRQVKT 240
                     .||...||:.|     |||:|...||..|...||||..||..:|..|||::.|||.
Human   243 GAEEGAPVTAGVTAPGGKSRRRRTAFTSEQLLELEKEFHCKKYLSLTERSQIAHALKLSEVQVKI 307

  Fly   241 WFQNRRAKWRR---ANLSKRSASAQGPIAGAAVGSPSSASSSSVPV 283
            |||||||||:|   .|:|.||..   |:....:..|       :||
Human   308 WFQNRRAKWKRIKAGNVSSRSGE---PVRNPKIVVP-------IPV 343

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HHEX	NP_650938.2	Homeodomain	200..251	CDD:459649	30/55 (55%)
GBX1	NP_001092304.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31		4/6 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	128..265		25/139 (18%)
		Homeodomain	262..318	CDD:459649	30/55 (55%)