Protein Alignment HHEX and NKX2-8

DIOPT Version :10

• Sequence 1: NP_650938.2
• Gene: HHEX / 42495
• FlyBaseID: FBgn0038852
• Length: 323
• Species: Drosophila melanogaster
• Sequence 2: NP_055175.2
• Gene: NKX2-8 / 26257
• HGNCID: 16364
• Length: 239
• Species: Homo sapiens
• Alignment Length: 161
• Identity: 53/161 - (32%)
• Similarity: 73/161 - (45%)
• Gaps: 21/161 - (13%)

  Fly   147 QPTAYCDQYSPFT--MDCEGFPNPASAAAALYC---------NAYPAASFYMSNFGVKRKGGQIR 200
            :|.....|..|..  :|.|....|:|..::|..         :|.||:.   .:...|||..::.
Human    29 EPEPRAPQPDPCAAWLDSERGHYPSSDESSLETSPPDSSQRPSARPASP---GSDAEKRKKRRVL 90

  Fly   201 FTSQQTKNLEARFASSKYLSPEERRHLALQLKLTDRQVKTWFQNRRAKWRRANLSKRSASAQGPI 265
            |:..||..||.||...:|||..||..||..|:||..|||.||||.|.|.:||   :...:|:.|.
Human    91 FSKAQTLELERRFRQQRYLSAPEREQLASLLRLTPTQVKIWFQNHRYKLKRA---RAPGAAESPD 152

  Fly   266 AGAAV---GSPSSASSSSVPVLNLGSGSRCG 293
            ..|:.   .:|.......|||| :..|..||
Human   153 LAASAELHAAPGLLRRVVVPVL-VRDGQPCG 182

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HHEX	NP_650938.2	Homeodomain	200..251	CDD:459649	26/50 (52%)
NKX2-8	NP_055175.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..87		14/60 (23%)
		Homeodomain	85..141	CDD:459649	27/55 (49%)