Protein Alignment HHEX and Nkx2-4

DIOPT Version :10

• Sequence 1: NP_650938.2
• Gene: HHEX / 42495
• FlyBaseID: FBgn0038852
• Length: 323
• Species: Drosophila melanogaster
• Sequence 2: NP_075993.1
• Gene: Nkx2-4 / 228731
• MGIID: 97349
• Length: 354
• Species: Mus musculus
• Alignment Length: 287
• Identity: 79/287 - (27%)
• Similarity: 102/287 - (35%)
• Gaps: 60/287 - (20%)

  Fly    32 GSSQSPVAVTAGIATPHALAMPKASLATGSSSAAPTPSPSSATNIYDLSREAAAAQYAMKSMDSS 96
            |.|....||.||:..|||:|...|:.|..:::||                .||||.|.|
Mouse    53 GPSSQAAAVAAGMQPPHAMAGHNAAAAAAAAAAA----------------AAAAATYHM------ 95

  Fly    97 AVLAPTSLRFNPIYPDPASLFYQQVLQLQKNPSL----FMPHFQAAAVAAAAAVQPTAYCDQYSP 157
                          |...|.|....:....|..|    .:|.:.......|||.....|.....|
Mouse    96 --------------PPGVSQFPHSAMGSYCNGGLGNMGELPAYTDGMRGGAAAAATGWYGANTDP 146

  Fly   158 FTMDCEGFPNPASAA-----AALYCNAYPAASFYMSNFGVKRKGGQIRFTSQQTKNLEARFASSK 217
            .......|..|::..     .:|...|..|.|....:....|:..::.|:..|...||.||...|
Mouse   147 RYSSISRFMGPSAGVNVAGMGSLTGIADAAKSLAPLHAAAPRRKRRVLFSQAQVYELERRFKQQK 211

  Fly   218 YLSPEERRHLALQLKLTDRQVKTWFQNRRAKWRRANLSKRSASAQ--GPIAGAAVGSPSSASSSS 280
            |||..||.|||..:.||..|||.||||.|.|.:|....|.:...|  |.:.......|.|....:
Mouse   212 YLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQLQQEGGLGPPPPPPPPSPRRVA 276

  Fly   281 VPVLNLGSGSRC------------GQQ 295
            |||| :..|..|            |||
Mouse   277 VPVL-VKDGKPCQNGAGTPTPGQGGQQ 302

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HHEX	NP_650938.2	Homeodomain	200..251	CDD:459649	26/50 (52%)
Nkx2-4	NP_075993.1	Homeodomain	189..245	CDD:459649	26/55 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	245..329		15/59 (25%)