Protein Alignment HHEX and Nkx2-1

DIOPT Version :10

• Sequence 1: NP_650938.2
• Gene: HHEX / 42495
• FlyBaseID: FBgn0038852
• Length: 323
• Species: Drosophila melanogaster
• Sequence 2: NP_001390509.1
• Gene: Nkx2-1 / 21869
• MGIID: 108067
• Length: 423
• Species: Mus musculus
• Alignment Length: 313
• Identity: 77/313 - (24%)
• Similarity: 107/313 - (34%)
• Gaps: 84/313 - (26%)

  Fly    12 FSIENILEQKSSSHRSQSRRGSS-QSPVAV-TAGIATPHALAMPKASLATGSSSAAPTPSPSSAT 74
            ||:.:||.....|::.....|.. .:|:|. ..|.|.|.|.||.:.  |.|...|.......:|.
Mouse    62 FSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPAAAMQQH--AVGHHGAVTAAYHMTAA 124

  Fly    75 NIYDLSREAAAAQYAMKSMDSSAVLAPTSLRFNPIYPDPASLFYQQVLQLQKNPSLFMPHFQAAA 139
            .:..||..|... |...::.:.:.|.|                ||..::
Mouse   125 GVPQLSHSAVGG-YCNGNLGNMSELPP----------------YQDTMR---------------- 156

  Fly   140 VAAAAAVQPTAYCDQYSPFTMDCEGFPNPASAAAALYCNAYPAASFYMSNFG------------- 191
               .:|..|..|           ...|:|...|.:.:..  ||:...||..|
Mouse   157 ---NSASGPGWY-----------GANPDPRFPAISRFMG--PASGMNMSGMGGLGSLGDVSKNMA 205

  Fly   192 ----VKRKGGQIRFTSQQTKNLEARFASSKYLSPEERRHLALQLKLTDRQVKTWFQNRRAKWRR- 251
                ..|:..::.|:..|...||.||...||||..||.|||..:.||..|||.||||.|.|.:|
Mouse   206 PLPSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQ 270

  Fly   252 -----ANLSKRSASAQGPIAGAAVGSPSSASSS-------SVPVLNLGSGSRC 292
                 |....:..|..|...|...|.|....:.       :|||| :..|..|
Mouse   271 AKDKAAQQQLQQDSGGGGGGGGGAGCPQQQQAQQQSPRRVAVPVL-VKDGKPC 322

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HHEX	NP_650938.2	Homeodomain	200..251	CDD:459649	26/50 (52%)
Nkx2-1	NP_001390509.1	Homeodomain	213..269	CDD:459649	26/55 (47%)