Protein Alignment HHEX and EN1

DIOPT Version :10

• Sequence 1: NP_650938.2
• Gene: HHEX / 42495
• FlyBaseID: FBgn0038852
• Length: 323
• Species: Drosophila melanogaster
• Sequence 2: NP_001417.3
• Gene: EN1 / 2019
• HGNCID: 3342
• Length: 392
• Species: Homo sapiens
• Alignment Length: 309
• Identity: 75/309 - (24%)
• Similarity: 113/309 - (36%)
• Gaps: 94/309 - (30%)

  Fly    12 FSIENILEQKSSSHRSQSRRGSSQSPVAVTA--GIATPHALAMPKASLATGSSSAAP--TPSPSS 72
            |.|:|||.......:.|.   ..|..||..|  |......:...:...|.|.....|  |.:|.:
Human   105 FFIDNILRPDFGCKKEQP---PPQLLVAAAARGGAGGGGRVERDRGQTAAGRDPVHPLGTRAPGA 166

  Fly    73 ATNIY---------DLSREAAAAQYAMKSMDSSAVLAPTSLRFNPIYPDPASLFYQQVLQLQKNP 128
            |:.:.         |.|:.|||...|.|:.:.:|..|..
Human   167 ASLLCAPDANCGPPDGSQPAAAGAGASKAGNPAAAAAAA-------------------------- 205

  Fly   129 SLFMPHFQAAAVAAAAA----------------------VQPTAYCDQYSPFTM---DCEGFP-- 166
                    |||||||||                      .|.|.|.:..:|..:   ...|.|
Human   206 --------AAAVAAAAAAAAAKPSDTGGGGSGGGAGSPGAQGTKYPEHGNPAILLMGSANGGPVV 262

  Fly   167 -----NPASAAAALYCNAY---PAASFYMSNFGVKR-----KGGQIRFTSQQTKNLEARFASSKY 218
                 .|....|.:||..|   |::.........|:     |..:..||::|.:.|:|.|.:::|
Human   263 KTDSQQPLVWPAWVYCTRYSDRPSSGPRTRKLKKKKNEKEDKRPRTAFTAEQLQRLKAEFQANRY 327

  Fly   219 LSPEERRHLALQLKLTDRQVKTWFQNRRAKWRRANLSKRSAS----AQG 263
            ::.:.|:.||.:|.|.:.|:|.||||:|||.::|...|...:    |||
Human   328 ITEQRRQTLAQELSLNESQIKIWFQNKRAKIKKATGIKNGLALHLMAQG 376

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HHEX	NP_650938.2	Homeodomain	200..251	CDD:459649	21/50 (42%)
EN1	NP_001417.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..100
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	132..164		6/31 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	219..251		4/31 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	282..306		3/23 (13%)
		Homeodomain	305..360	CDD:459649	21/54 (39%)
		Engrail_1_C_sig	361..391	CDD:431338	5/16 (31%)