Protein Alignment HHEX and EMX1

DIOPT Version :10

• Sequence 1: NP_650938.2
• Gene: HHEX / 42495
• FlyBaseID: FBgn0038852
• Length: 323
• Species: Drosophila melanogaster
• Sequence 2: NP_004088.2
• Gene: EMX1 / 2016
• HGNCID: 3340
• Length: 290
• Species: Homo sapiens
• Alignment Length: 284
• Identity: 68/284 - (23%)
• Similarity: 100/284 - (35%)
• Gaps: 102/284 - (35%)

  Fly    45 ATPHALAMPKASLATGSSSAAPTPSPSSATNIYDLSRE--------------------AAAAQYA 89
            |.|...|:|:|.|        |..:|::||.....::.                    ..|..:.
Human    12 AAPGRGALPRARL--------PRTAPAAATMFQPAAKRGFTIESLVAKDGGTGGGTGGGGAGSHL 68

  Fly    90 MKSMDSSAVLAPTSLRFNPIYPDPASLFYQQVLQLQKNPSLFMPHFQAAAVAAAA--------AV 146
            :.:..|...|.||:|.    ||.|::.           .:.|:..|.|||.|.|.        .|
Human    69 LAAAASEEPLRPTALN----YPHPSAA-----------EAAFVSGFPAAAAAGAGRSLYGGPELV 118

  Fly   147 QPTAYCDQYSPFTMDCEGFPNPASAAAALYCNAYPAASFYMSN----------------FGVK-- 193
            .|.|.  .:...|:      :||....|  ....|..||:.:.                ||.:
Human   119 FPEAM--NHPALTV------HPAHQLGA--SPLQPPHSFFGAQHRDPLHFYPWVLRNRFFGHRFQ 173

  Fly   194 ----------------RKGGQIR--FTSQQTKNLEARFASSKYLSPEERRHLALQLKLTDRQVKT 240
                            ||..:||  |:..|...||..|..:.|:...||:.||..|.|::.|||.
Human   174 ASDVPQDGLLLHGPFARKPKRIRTAFSPSQLLRLERAFEKNHYVVGAERKQLAGSLSLSETQVKV 238

  Fly   241 WFQNRRAKWRRANLSKRSASAQGP 264
            ||||||.|::|..|.:     :||
Human   239 WFQNRRTKYKRQKLEE-----EGP 257

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HHEX	NP_650938.2	Homeodomain	200..251	CDD:459649	23/52 (44%)
EMX1	NP_004088.2	Homeodomain	193..249	CDD:459649	24/55 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	249..290		4/14 (29%)