Protein Alignment HHEX and Pitx1

DIOPT Version :10

• Sequence 1: NP_650938.2
• Gene: HHEX / 42495
• FlyBaseID: FBgn0038852
• Length: 323
• Species: Drosophila melanogaster
• Sequence 2: NP_035227.1
• Gene: Pitx1 / 18740
• MGIID: 107374
• Length: 315
• Species: Mus musculus
• Alignment Length: 147
• Identity: 38/147 - (25%)
• Similarity: 64/147 - (43%)
• Gaps: 50/147 - (34%)

  Fly   193 KRKGGQIRFTSQQTKNLEARFASSKYLSPEERRHLALQLKLTDRQVKTWFQNRRAKWRR------ 251
            |::..:..|||||.:.|||.|..::|.....|..:|:...||:.:|:.||:|||||||:
Mouse    89 KQRRQRTHFTSQQLQELEATFQRNRYPDMSMREEIAVWTNLTEPRVRVWFKNRRAKWRKRERNQQ 153

  Fly   252 ---------------------------------------ANLSKRS---ASAQGPIAGAAV-GSP 273
                                                   |.||.:|   .::..|::..:: .:|
Mouse   154 LDLCKGGYVPQFSGLVQPYEDVYAAGYSYNNWAAKSLAPAPLSTKSFTFFNSMSPLSSQSMFSAP 218

  Fly   274 SSASSSSVPVLNLGSGS 290
            ||.||.::| .::|.|:
Mouse   219 SSISSMTMP-SSMGPGA 234

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HHEX	NP_650938.2	Homeodomain	200..251	CDD:459649	23/50 (46%)
Pitx1	NP_035227.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..104		6/14 (43%)
		Homeodomain	91..147	CDD:459649	23/55 (42%)
		Interaction with PIT-1	151..280		13/85 (15%)
		OAR	277..294	CDD:461067
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	281..294
		Nuclear localization signal. /evidence=ECO:0000255	287..291