Protein Alignment HHEX and Nkx2-2

DIOPT Version :10

• Sequence 1: NP_650938.2
• Gene: HHEX / 42495
• FlyBaseID: FBgn0038852
• Length: 323
• Species: Drosophila melanogaster
• Sequence 2: NP_035049.1
• Gene: Nkx2-2 / 18088
• MGIID: 97347
• Length: 273
• Species: Mus musculus
• Alignment Length: 288
• Identity: 75/288 - (26%)
• Similarity: 109/288 - (37%)
• Gaps: 79/288 - (27%)

  Fly     7 SSKAAFSIENILEQKSSSHRSQSRRGSSQSPVAVTAGIATPHALAMPKASLATGSSSAAPTPSP- 70
            ::|..||:::||:...::....|   .::.|...:.| ..|...|.|....|..:..:.|..||
Mouse     5 NTKTGFSVKDILDLPDTNDEDGS---VAEGPEEESEG-PEPAKRAGPLGQGALDAVQSLPLKSPF 65

  Fly    71 -SSATNIYDLSREAAAAQYAMKSMDSSAVLAPTSLRFNPIYPDPASLFYQQVLQLQKNPSLFMPH 134
             .|:.|.|  :|..|:.:....|:...|..||         |..:|         .|:|
Mouse    66 YDSSDNPY--TRWLASTEGLQYSLHGLAASAP---------PQDSS---------SKSP------ 104

  Fly   135 FQAAAVAAAAAVQPTAYCDQYSPFTMDCEGFPNPASAAAALYCNAYPAASFYMSNFGVKRKGGQI 199
                        :|:|  |:......:.:|....|                     |.||| .::
Mouse   105 ------------EPSA--DESPDNDKETQGGGGDA---------------------GKKRK-RRV 133

  Fly   200 RFTSQQTKNLEARFASSKYLSPEERRHLALQLKLTDRQVKTWFQNRRAKWRRANLSKRSASAQGP 264
            .|:..||..||.||...:|||..||.|||..::||..|||.||||.|.|.:||...|
Mouse   134 LFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKRARAEK-------- 190

  Fly   265 IAGAAVGSPSSASSSSVPVLNLGSGSRC 292
              |..|....|....:|||| :..|..|
Mouse   191 --GMEVTPLPSPRRVAVPVL-VRDGKPC 215

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HHEX	NP_650938.2	Homeodomain	200..251	CDD:459649	26/50 (52%)
Nkx2-2	NP_035049.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..56		12/54 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	91..131		16/99 (16%)
		Homeodomain	129..185	CDD:459649	28/56 (50%)