Protein Alignment HHEX and GSX2

DIOPT Version :10

• Sequence 1: NP_650938.2
• Gene: HHEX / 42495
• FlyBaseID: FBgn0038852
• Length: 323
• Species: Drosophila melanogaster
• Sequence 2: NP_573574.2
• Gene: GSX2 / 170825
• HGNCID: 24959
• Length: 304
• Species: Homo sapiens
• Alignment Length: 312
• Identity: 82/312 - (26%)
• Similarity: 114/312 - (36%)
• Gaps: 107/312 - (34%)

  Fly    37 PVAVTAGIATPHALAMPKASLATGSSSAAPTPSPSSATNIYDLSREAAAAQYAMKSMDSSAVLAP 101
            |:.||:     | |...:.|:..||..|....:.:..:.:    ..||.|...:|...||   ||
Human    62 PLCVTS-----H-LHSSRGSVGAGSGGAGAGVTGAGGSGV----AGAAGALPLLKGQFSS---AP 113

  Fly   102 TSLRFNP--------IYPDPASLFYQQVLQLQKNPSLFMPHFQAAAVAAAAAVQPTAYCDQYSPF 158
            ...:|.|        .:|......:.|..|         |...|||.|||||
Human   114 GDAQFCPRVNHAHHHHHPPQHHHHHHQPQQ---------PGSAAAAAAAAAA------------- 156

  Fly   159 TMDCEGFPNPASAAAAL--------YCNA--YPAAS---FYMSNFGVK-----RKGGQIR--FTS 203
                      |:|||||        .|.|  |..|.   |:....|..     ..|.::|  |||
Human   157 ----------AAAAAALGHPQHHAPVCTATTYNVADPRRFHCLTMGGSDASQVPNGKRMRTAFTS 211

  Fly   204 QQTKNLEARFASSKYLSPEERRHLALQLKLTDRQVKTWFQNRRAKWRRANLSKRSASAQGPIAGA 268
            .|...||..|:|:.|||...|..:|..|.|:::|||.||||||.|.::.....:.
Human   212 TQLLELEREFSSNMYLSRLRRIEIATYLNLSEKQVKIWFQNRRVKHKKEGKGTQR---------- 266

  Fly   269 AVGSPSSASSSSVPVLNLGSGSRC-GQQ-----SDEEDRMYLSEDDEDDDED 314
                            |..:|.:| |.|     |::||.  ||....:||::
Human   267 ----------------NSHAGCKCVGSQVHYARSEDEDS--LSPASANDDKE 300

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HHEX	NP_650938.2	Homeodomain	200..251	CDD:459649	26/52 (50%)
GSX2	NP_573574.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	116..151		8/43 (19%)
		Homeodomain	203..259	CDD:459649	26/55 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	283..304		7/20 (35%)