Protein Alignment HHEX and tlx2

DIOPT Version :10

• Sequence 1: NP_650938.2
• Gene: HHEX / 42495
• FlyBaseID: FBgn0038852
• Length: 323
• Species: Drosophila melanogaster
• Sequence 2: XP_005173139.1
• Gene: tlx2 / 170781
• ZFINID: ZDB-GENE-020208-1
• Length: 309
• Species: Danio rerio
• Alignment Length: 276
• Identity: 76/276 - (27%)
• Similarity: 106/276 - (38%)
• Gaps: 69/276 - (25%)

  Fly    11 AFSIENIL--EQKSSSHRSQSRRGSSQSPVAVTAGIATPHALAMPKASLATGSSSAAPTPSPSSA 73
            :|.|:.||  ..:|||....||.|...  .|:|..:...:....|..|:|.|.:.:
Zfish    20 SFGIDQILNGSDQSSSCMLPSRTGDPD--YALTPNVYNGYNSMYPACSMAAGLAGS--------- 73

  Fly    74 TNIYDLSREAAAA---QYAMKSMDSSAVLAPTSLRFNPIYP------DPASLFYQQVLQLQKNPS 129
               |:::.....:   ...:.|.::..|:...:.|..|..|      .|.|: ...:..:...||
Zfish    74 ---YNVNMNMNVSMNMNVNVNSGNAGGVIRVPAHRPMPPAPHQPTAGHPPSI-AAGIPTMPTVPS 134

  Fly   130 LFMPH------------FQAAAVAAAAAVQPTAYCDQYSPFTMDCE-GFPNPASAAAALYCNAYP 181
            :..||            |....:.||           .|||::... |.|         |.|..|
Zfish   135 MGSPHSFTFPWMESSRRFAKDRLTAA-----------LSPFSVTRRIGHP---------YQNRTP 179

  Fly   182 AASFYMSNFGVKRKGGQIRFTSQQTKNLEARFASSKYLSPEERRHLALQLKLTDRQVKTWFQNRR 246
            .          |||..:..|:..|...||.||...|||:..||..||..||:||.||||||||||
Zfish   180 P----------KRKKPRTSFSRVQICELEKRFHRQKYLASAERATLAKALKMTDAQVKTWFQNRR 234

  Fly   247 AKWRRANLSKRSASAQ 262
            .||||....:|.|..|
Zfish   235 TKWRRQTAEEREAERQ 250

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HHEX	NP_650938.2	Homeodomain	200..251	CDD:459649	29/50 (58%)
tlx2	XP_005173139.1	Homeodomain	183..239	CDD:459649	30/55 (55%)