Protein Alignment HHEX and NKX6-3

DIOPT Version :10

• Sequence 1: NP_650938.2
• Gene: HHEX / 42495
• FlyBaseID: FBgn0038852
• Length: 323
• Species: Drosophila melanogaster
• Sequence 2: NP_001351770.1
• Gene: NKX6-3 / 157848
• HGNCID: 26328
• Length: 265
• Species: Homo sapiens
• Alignment Length: 271
• Identity: 71/271 - (26%)
• Similarity: 100/271 - (36%)
• Gaps: 55/271 - (20%)

  Fly    57 LATGSSSAAPTPSPSSATNIYDLS------REAAAAQYAMKSMDSSAVLAPTSLRFNPIYPDPAS 115
            ||......||....|...:.|.||      :.||...:.:..:.|..|.||.:...:. ||..|.
Human    16 LAQFPEMKAPVCQYSVQNSFYKLSPPGLGPQLAAGTPHGITDILSRPVAAPNNSLLSG-YPHVAG 79

  Fly   116 LFYQQVLQLQKNPSLFMPHFQAAAVAAAAAVQPTAYCDQYSPFTMD------CEGFPNPASAAAA 174
            ..     .|......:.|  |....:.|....||...:.::....|      |...|:|.|.:..
Human    80 FG-----GLSSQGVYYSP--QVGNFSKAGNEYPTRTRNCWADTGQDWRGGRQCSNTPDPLSDSIH 137

  Fly   175 LYCNAYPAASFYMSNFGVKRKGGQIRFTSQQTKNLEARFASSKYLSPEERRHLALQLKLTDRQVK 239
                              |:|..:..||..|...||..|..:|||:..||..||..|.:|:.|||
Human   138 ------------------KKKHTRPTFTGHQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVK 184

  Fly   240 TWFQNRRAKWRRANLSKRSASAQGPIAGAAVGSPSSASSSSVPVLNLGSGSRCGQQSDEEDRMYL 304
            .||||||.|||:.:..:.|:|......||..|:               .|.|.  .|:.||..|.
Human   185 VWFQNRRTKWRKKSALEPSSSTPRAPGGAGAGA---------------GGDRA--PSENEDDEYN 232

  Fly   305 SEDDEDDDEDE 315
            ...|.|.|:::
Human   233 KPLDPDSDDEK 243

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HHEX	NP_650938.2	Homeodomain	200..251	CDD:459649	26/50 (52%)
NKX6-3	NP_001351770.1	Homeodomain	138..196	CDD:459649	28/57 (49%)