Protein Alignment HHEX and Hoxd8

DIOPT Version :10

• Sequence 1: NP_650938.2
• Gene: HHEX / 42495
• FlyBaseID: FBgn0038852
• Length: 323
• Species: Drosophila melanogaster
• Sequence 2: NP_032302.2
• Gene: Hoxd8 / 15437
• MGIID: 96209
• Length: 289
• Species: Mus musculus
• Alignment Length: 287
• Identity: 67/287 - (23%)
• Similarity: 89/287 - (31%)
• Gaps: 103/287 - (35%)

  Fly    76 IYDLSREAAAAQYAMKSMDSSAVLAPTSLRFNPIYPD-----PASLFYQQVLQLQKNPSLFMPH- 134
            :|...:.||||.       ::|..|......||.|.|     ..|..:...|||..|.:...||
Mouse     9 LYSKYKAAAAAA-------AAAAAAAAGEAINPTYYDCHFAPEVSGRHAAALQLYGNSAAGFPHA 66

  Fly   135 --------------------------FQAAAVAAAAAVQPTAYCDQYSPFTMDCEGFPNPASAAA 173
                                      |.|.|.:..||.|.........|        |.|.....
Mouse    67 HPHPHPHPSPPPGCGGGGGPGPGQDYFHAGAGSPTAAYQAAPPPPHPPP--------PPPPPPCG 123

  Fly   174 ALYCNAYPAASFY----------------------------MSNFGVK----------------- 193
            .:.|:..| |.||                            ..|.|..
Mouse   124 GIACHGEP-AKFYGYDNLQRQPIFTTQQEAELVQYPDCKSSSGNIGEDPDHLNQSSSPSQMFPWM 187

  Fly   194 -------RKGGQIRFTSQQTKNLEARFASSKYLSPEERRHLALQLKLTDRQVKTWFQNRRAKWRR 251
                   |:.|:..::..||..||..|..:.||:.:.|..::..|.||:||||.||||||.||::
Mouse   188 RPQAAPGRRRGRQTYSRFQTLELEKEFLFNPYLTRKRRIEVSHTLALTERQVKIWFQNRRMKWKK 252

  Fly   252 ANLSKRSASAQGPIAGAAVGSPSSASS 278
            .| :|....|..|  .|..|.|....|
Mouse   253 EN-NKDKFPASRP--EAKDGDPKKEVS 276

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HHEX	NP_650938.2	Homeodomain	200..251	CDD:459649	23/50 (46%)
Hoxd8	NP_032302.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	62..125		11/70 (16%)
		COG5576	139..272	CDD:227863	33/135 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	162..184		2/21 (10%)
		Antp-type hexapeptide	183..188		0/4 (0%)
		Homeodomain	196..252	CDD:459649	24/55 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	252..289		8/28 (29%)