Protein Alignment HHEX and GSC

DIOPT Version :10

• Sequence 1: NP_650938.2
• Gene: HHEX / 42495
• FlyBaseID: FBgn0038852
• Length: 323
• Species: Drosophila melanogaster
• Sequence 2: NP_776248.1
• Gene: GSC / 145258
• HGNCID: 4612
• Length: 257
• Species: Homo sapiens
• Alignment Length: 336
• Identity: 84/336 - (25%)
• Similarity: 111/336 - (33%)
• Gaps: 120/336 - (35%)

  Fly    12 FSIENILEQKSSSHRSQSRRGSSQSPVAVTAGIATPHALAMPKASLATGSSSAAPTPSPS-SATN 75
            |||:|||       .::.|...|..|||                     .|:|||...|: ...:
Human     6 FSIDNIL-------AARPRCKDSVLPVA---------------------HSAAAPVVFPALHGDS 42

  Fly    76 IYDLSREAAAAQYAMKSMDSSAVLAPTSLRFNPIYPDPASL--------------FYQQVLQLQK 126
            :|..|..|        |.|..|...      .|:.|..|.|              ||.|:
Human    43 LYGASGGA--------SSDYGAFYP------RPVAPGGAGLPAAVSGSRLGYNNYFYGQL----- 88

  Fly   127 NPSLFMPHFQAAAV--AAAAAVQPTAYCDQYSPFTMDCEGFPNPA--SAAAALYCNAYPAASFYM 187
                   |.|||.|  |...||.|..        ...|...|.|.  ....::..:..|......
Human    89 -------HVQAAPVGPACCGAVPPLG--------AQQCSCVPTPPGYEGPGSVLVSPVPHQMLPY 138

  Fly   188 SNFGV----------------KRKGGQIRFTSQQTKNLEARFASSKYLSPEERRHLALQLKLTDR 236
            .|.|.                ||:...| ||.:|.:.||..|..:||.....|..||.::.|.:.
Human   139 MNVGTLSRTELQLLNQLHCRRKRRHRTI-FTDEQLEALENLFQETKYPDVGTREQLARKVHLREE 202

  Fly   237 QVKTWFQNRRAKWRRANLSKRSASAQGPIAGAAVGSPSSASSSSVPVLNLGSGSRCGQQSDEEDR 301
            :|:.||:||||||||   .|||               ||..|.:....|..|.|:...:..||:
Human   203 KVEVWFKNRRAKWRR---QKRS---------------SSEESENAEKWNKTSSSKASPEKREEE- 248

  Fly   302 MYLSEDDEDDD 312
               .:.|.|.|
Human   249 ---GKSDLDSD 256

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HHEX	NP_650938.2	Homeodomain	200..251	CDD:459649	21/50 (42%)
GSC	NP_776248.1	Homeodomain	161..217	CDD:459649	23/56 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	213..257		19/66 (29%)