Protein Alignment HHEX and NKX2-6

DIOPT Version :10

• Sequence 1: NP_650938.2
• Gene: HHEX / 42495
• FlyBaseID: FBgn0038852
• Length: 323
• Species: Drosophila melanogaster
• Sequence 2: NP_001129743.2
• Gene: NKX2-6 / 137814
• HGNCID: 32940
• Length: 301
• Species: Homo sapiens
• Alignment Length: 257
• Identity: 67/257 - (26%)
• Similarity: 94/257 - (36%)
• Gaps: 74/257 - (28%)

  Fly    67 TPSPSSATNIYDLSREAAAAQYAMKSMDSSAVLAPTSLRFNPIYPDPASLFYQQVLQLQKNPSLF 131
            |.:|.|..:|..|.||        :|..:::             |.|         :::|:|..|
Human     7 TSTPFSVKDILRLERE--------RSCPAAS-------------PHP---------RVRKSPENF 41

  Fly   132 MPHFQAAAVAAAAAVQ----------------PTAYCDQYSPFTMDCE--GFPNPASAAAALYCN 178
            . :.:..|....:.|.                |...|:  :...||.|  |.|.|...||:....
Human    42 Q-YLRMDAEPRGSEVHNAGGGGGDRKLDGSEPPGGPCE--AVLEMDAERMGEPQPGLNAASPLGG 103

  Fly   179 AYPAASFYMSNFGVKRKGG-------------QIRFTSQQTKNLEARFASSKYLSPEERRHLALQ 230
            ........:.|.|...:||             ::.|:..|...||.||...:|||..||.|||..
Human   104 GTRVPERGVGNSGDSVRGGRSEQPKARQRRKPRVLFSQAQVLALERRFKQQRYLSAPEREHLASA 168

  Fly   231 LKLTDRQVKTWFQNRRAKWRRANLSKRSASAQGPIAGAAVGSPSSASSSSVPVLNLGSGSRC 292
            |:||..|||.||||||.|.:|....|....|         |.|.:....:|||| :..|..|
Human   169 LQLTSTQVKIWFQNRRYKCKRQRQDKSLELA---------GHPLTPRRVAVPVL-VRDGKPC 220

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HHEX	NP_650938.2	Homeodomain	200..251	CDD:459649	27/50 (54%)
NKX2-6	NP_001129743.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..135		23/145 (16%)
		Homeodomain	133..189	CDD:459649	27/55 (49%)