Protein Alignment HHEX and DBX1

DIOPT Version :10

• Sequence 1: NP_650938.2
• Gene: HHEX / 42495
• FlyBaseID: FBgn0038852
• Length: 323
• Species: Drosophila melanogaster
• Sequence 2: NP_001025036.2
• Gene: DBX1 / 120237
• HGNCID: 33185
• Length: 343
• Species: Homo sapiens
• Alignment Length: 374
• Identity: 86/374 - (22%)
• Similarity: 133/374 - (35%)
• Gaps: 134/374 - (35%)

  Fly     7 SSKAAFSIENILEQKSSSHRSQSRRGSSQSPVAVTAGIATPHALAMPKASLATGSSS-AAPTP-- 68
            |..::|.:|:::         :..|..:..|.:|.....:|.....|.|...||:|. .:|.|
Human    34 SGHSSFLVEDLI---------RISRPPAYLPRSVPTASMSPPRQGAPTALTDTGASDLGSPGPGS 89

  Fly    69 ----SPSSATNIYDLSREAAAAQYAMKSMDSSAVLAPTSLRFNPIYPDPASLFYQQVLQLQKNPS 129
                ||.:|   :..:.|....::.:.::.||.....||         ||      :||.....:
Human    90 RRGGSPPTA---FSPASETTFLKFGVNAILSSGPRTETS---------PA------LLQSVPPKT 136

  Fly   130 LFMPHFQAAAVAAAAAVQPTAYCDQYSPFTMDCEGFPNPASAAAALYCNAYPAASFYMSNFGVKR 194
            ...|:|:.:                :.|| :....||..:|........::|.|:     .|..|
Human   137 FAFPYFEGS----------------FQPF-IRSSYFPASSSVVPIPGTFSWPLAA-----RGKPR 179

  Fly   195 KGGQIR--FTSQQTKNLEARFASSKYLSPEERRHLALQLKLTDRQVKTWFQNRRAKWRRANLSKR 257
            :|...|  |:..|.|.||..|...||:|..:|:.||.:|.|.|.|||.||||||.|||.:...:.
Human   180 RGMLRRAVFSDVQRKALEKMFQKQKYISKPDRKKLAAKLGLKDSQVKIWFQNRRMKWRNSKEREL 244

  Fly   258 SASA-------------------------------QGPIAGAAVGSPS----------------- 274
            .:|.                               :||      ||||
Human   245 LSSGGCREQTLPTKLNPHPDLSDVGQKGPGNEEEEEGP------GSPSHRLAYHASSDPQHLRDP 303

  Fly   275 --------SASSSSVPVLNLGSGSRCGQQSDEEDRMYLSEDDEDDDEDE 315
                    |.:.||.|          |:.||..|    ||::|:.:|.|
Human   304 RLPGPLPPSPAHSSSP----------GKPSDFSD----SEEEEEGEEQE 338

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HHEX	NP_650938.2	Homeodomain	200..251	CDD:459649	27/52 (52%)
DBX1	NP_001025036.2	PRK12323	<49..182	CDD:481241	34/172 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	56..100		12/46 (26%)
		Homeodomain	184..238	CDD:459649	27/53 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	240..343		20/119 (17%)