Protein Alignment HHEX and HOXB13

DIOPT Version :10

• Sequence 1: NP_650938.2
• Gene: HHEX / 42495
• FlyBaseID: FBgn0038852
• Length: 323
• Species: Drosophila melanogaster
• Sequence 2: NP_006352.2
• Gene: HOXB13 / 10481
• HGNCID: 5112
• Length: 284
• Species: Homo sapiens
• Alignment Length: 252
• Identity: 64/252 - (25%)
• Similarity: 103/252 - (40%)
• Gaps: 57/252 - (22%)

  Fly    43 GIATPHALAMPKASLATGSSSAAPTPSP------------SSATNIYDLSREAAAAQYAMKSMDS 95
            |.|.|.....|...:..|:|   |.|.|            .|.:::...::.|..|.|..::..:
Human    55 GSAEPPKQCHPCPGVPQGTS---PAPVPYGYFGGGYYSCRVSRSSLKPCAQAATLAAYPAETPTA 116

  Fly    96 SAVL--APTSLRFNPIYPDP----ASLFYQQVLQLQKNPS-------LFMPHFQAAAVAAAAAVQ 147
            ....  .||...|.|.||..    ||.....|:|....|.       |.:..:|:.|:|.....|
Human   117 GEEYPSRPTEFAFYPGYPGTYQPMASYLDVSVVQTLGAPGEPRHDSLLPVDSYQSWALAGGWNSQ 181

  Fly   148 PTAYCDQYSPFTMDCEGFPNPA----SAAAALYCNAYP--AASFYMSNFGVKRKG--GQIRFTSQ 204
                        |.|:|..||.    .||.|.....:|  |.:|        |:|  .:|.::..
Human   182 ------------MCCQGEQNPPGPFWKAAFADSSGQHPPDACAF--------RRGRKKRIPYSKG 226

  Fly   205 QTKNLEARFASSKYLSPEERRHLALQLKLTDRQVKTWFQNRRAKWRRANLSKRSASA 261
            |.:.||..:|::|:::.::||.::....|::||:..||||||.|.::. |:|...||
Human   227 QLRELEREYAANKFITKDKRRKISAATSLSERQITIWFQNRRVKEKKV-LAKVKNSA 282

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HHEX	NP_650938.2	Homeodomain	200..251	CDD:459649	17/50 (34%)
HOXB13	NP_006352.2	HoxA13_N	12..123	CDD:463521	13/70 (19%)
		Homeodomain	217..273	CDD:459649	18/55 (33%)
		Interaction with DNA. /evidence=ECO:0000305|PubMed:28473536, ECO:0000305|Ref.8	217..246		6/28 (21%)
		Interaction with 5-mCpG DNA. /evidence=ECO:0000305|PubMed:28473536	258..269		7/10 (70%)
		Interaction with DNA. /evidence=ECO:0000305|PubMed:28473536, ECO:0000305|Ref.8	270..273		1/2 (50%)