Protein Alignment HHEX and nkx2-1

DIOPT Version :10

• Sequence 1: NP_650938.2
• Gene: HHEX / 42495
• FlyBaseID: FBgn0038852
• Length: 323
• Species: Drosophila melanogaster
• Sequence 2: XP_002935383.1
• Gene: nkx2-1 / 100135015
• XenbaseID: XB-GENE-485985
• Length: 346
• Species: Xenopus tropicalis
• Alignment Length: 260
• Identity: 67/260 - (25%)
• Similarity: 100/260 - (38%)
• Gaps: 46/260 - (17%)

  Fly    69 SPSSATNIYDLSREAAAAQYAMKSMDSSAVLAPTSLRFNPIYPDPASLFYQQVLQLQKNPSLFMP 133
            :|.|.::|.....|:    |...:|:|:.:.||.|..:.......||:  ||.......|.....
 Frog     9 TPFSVSDILSPLEES----YKKVAMESAGLGAPLSAAYRQSQVSQASM--QQHGMGHNGPVSAAY 67

  Fly   134 HFQAAAVAAAAAVQPTAYCD----------QYSPF--TM---DCEGF----PNPASAAAALYCNA 179
            |..||.|...:......||:          :..|:  ||   ...|:    |:|..:..:.:..
 Frog    68 HMTAAGVPQLSHTTMGGYCNGNLGNLGNMSELPPYQDTMRNSSATGWYGANPDPRFSTISRFMG- 131

  Fly   180 YPAASFYMSNFG-----------------VKRKGGQIRFTSQQTKNLEARFASSKYLSPEERRHL 227
             |::...|...|                 ..|:..::.|:..|...||.||...||||..||.||
 Frog   132 -PSSGMNMGGLGNMGSLGDVGKSMTPLQATPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHL 195

  Fly   228 ALQLKLTDRQVKTWFQNRRAKWRRANLSKRSASAQGPIAGAAVGSPSSASSSSVPVLNLGSGSRC 292
            |..:.||..|||.||||.|.|.:| ....::|..|.....::.....|....:|||| :..|..|
 Frog   196 ASMIHLTPTQVKIWFQNHRYKMKR-QAKDKAAQQQMQQDNSSCQQQQSPRRVAVPVL-VKDGKPC 258

  Fly   293  292
             Frog   259  258

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HHEX	NP_650938.2	Homeodomain	200..251	CDD:459649	26/50 (52%)
nkx2-1	XP_002935383.1	Homeodomain	163..219	CDD:459649	26/55 (47%)