DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dmrt93B and C18orf63

DIOPT Version :9

Sequence 1:	NP_524428.1	Gene:	dmrt93B / 42494	FlyBaseID:	FBgn0038851	Length:	325	Species:	Drosophila melanogaster
Sequence 2:	NP_001167594.1	Gene:	C18orf63 / 644041	HGNCID:	40037	Length:	685	Species:	Homo sapiens

Alignment Length:	284	Identity:	57/284 - (20%)
Similarity:	99/284 - (34%)	Gaps:	66/284 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 NKRPRLVANPKAT--KIVEPTPAKVTNRVPKCAR----CR---NH-----------GIISEL--- 55
            |.:...|..|..|  |::..:..:.|:|.|.||:    |.   :|           ||.|.|
Human   324 NIQEHKVKPPNLTTKKMLRASLTQATSRKPACAQSLLPCSVAVDHKVELSVSQPTSGIFSALHLQ 388

  Fly    56 ----RGHKKLCTYKNCKCAKCVLIFERQRIMAAQVALKRQQAVEDAIAMRLVANKTGRSIDALPP 116
                :|.||..:.:..:....||:..|.........|..|    ..|..:.|.....|.:.....
Human   389 PESVQGRKKSLSIRAPQVHSEVLMPNRGNTQVQHTNLSSQ----SNITPKFVPVFKNRLLQMNKN 449

  Fly   117 GNIFGLTVTQPSSPRAKREDDQVEKTISEVEQ--QH--------LKQREEEYSESPA---VAQDL 168
            .::.|       ||:.|:.|....|..|....  ||        :|.|.....:..|   :.|:.
Human   450 TSVLG-------SPKRKQHDVTQSKLFSLKTSMIQHDKLNLGPAIKNRYSSNIQMQAANNLNQEN 507

  Fly   169 SAPRRDNVSQTAIDMLAQLFP-QRKRSVLEL------------VLKRCDLDLIRAIENVSPTGKS 220
            |.|.::..::::.:|..  || .|.:|.:.|            |:...:|.::::..:....||.
Human   508 SRPLQEKNTESSENMTK--FPSSRGKSTVSLNKNKQLSNSAVFVVSNNNLGVVKSAVDFQMKGKE 570

  Fly   221 SPVDVTSNQLPSQEPGMLTTMPQP 244
            :.......|:..:..|.|....||
Human   571 NLTGKGITQILGKSHGSLKLKRQP 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dmrt93B	NP_524428.1	DM	39..85	CDD:279137	16/70 (23%)
dmrt93B	NP_524428.1	CUE_DMA	176..214	CDD:270553	8/50 (16%)
C18orf63	NP_001167594.1	DUF4708	7..280	CDD:292441
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	502..538		9/37 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	635..685
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3815
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900