DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dmrt93B and DMRTA1

DIOPT Version :9

Sequence 1:	NP_524428.1	Gene:	dmrt93B / 42494	FlyBaseID:	FBgn0038851	Length:	325	Species:	Drosophila melanogaster
Sequence 2:	NP_071443.2	Gene:	DMRTA1 / 63951	HGNCID:	13826	Length:	504	Species:	Homo sapiens

Alignment Length:	352	Identity:	102/352 - (28%)
Similarity:	137/352 - (38%)	Gaps:	132/352 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 RVPKCARCRNHGIISELRGHKKLCTYKNCKCAKCVLIFERQRIMAAQVALKRQQAVEDAIA---M 100
            |.||||||||||::|.|:|||:.|.:::|.||||.||.||||:|||||||:||||.|::.|   .
Human    93 RTPKCARCRNHGVVSALKGHKRFCRWRDCACAKCTLIAERQRVMAAQVALRRQQAQEESEARGLQ 157

  Fly   101 RLVANKTGRSIDALPPGN----------------------IFGL--------------TVTQPSS 129
            ||:.  :|.|   .|||.                      ..||              .|.|...
Human   158 RLLC--SGLS---WPPGGRASGGGGRAENPQSTGGPAAGAALGLGALRQASGSATPAFEVFQQDY 217

  Fly   130 PRAKREDDQ---------VEKTISEVEQQHLKQRE---------------EEYSESP-------- 162
            |..|:|..:         .|:.||:..|.:|....               .|||..|
Human   218 PEEKQEQKESKCESCQNGQEELISKSHQLYLGSSSRSNGVIGKQSIGSSISEYSNKPDSILSPHP 282

  Fly   163 -----------------------------AVAQDLSAPRRDNVSQTAIDMLAQLFPQRKRSVLEL 198
                                         ..|...|.|...:..:..:|:|.::||..:||.||.
Human   283 GEQSGGEESPRSLSSSDLESGNESEWVKDLTATKASLPTVSSRPRDPLDILTKIFPNYRRSRLEG 347

  Fly   199 VLKRCDLDLIRAIENVSPTGKSSPVDVTSNQLPSQEPGMLTTMPQPAPPRS------------SA 251
            :|:.|..|:::|||.|. .||....| ..|...|:|  :..|..|.|...|            ||
Human   348 ILRFCKGDVVQAIEQVL-NGKEHKPD-NRNLANSEE--LENTAFQRASSFSLAGIGFGTLGNKSA 408

  Fly   252 FRPVITDQYQSKSVVELKPPVFGGSAS 278
            |.|:   |..|.|        :||.:|
Human   409 FSPL---QTTSAS--------YGGDSS 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dmrt93B	NP_524428.1	DM	39..85	CDD:279137	30/45 (67%)
dmrt93B	NP_524428.1	CUE_DMA	176..214	CDD:270553	14/37 (38%)
DMRTA1	NP_071443.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		DM	93..139	CDD:279137	30/45 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	170..192		0/21 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	266..307		4/40 (10%)
		CUE_DMA_DMRTA1	325..364	CDD:270600	14/38 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3815
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12322
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3693
SonicParanoid	1	1.000	-	-		X984
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.900